Little is known regarding the process by which teens succeed or fail after treatment for alcohol abuse or their long- term clinical course. In contrast to adult findings, our current research has found that adolescents receiving alcohol treatment demonstrate developmentally related differences in the relapse process, strategies through which they successfully abstain after treatment, and clinical course for up to four years after treatment. Additionally, it has become evident, that psychiatric co-morbidity influences outcome for adolescent alcohol abusers. For example, we have found that alcohol abusing teens with concomitant conduct disorder demonstrate greater relapse rate, briefer periods of sustained abstinence, less forethought regarding relapse risk, and fewer cognitive coping strategies than alcohol abusing teens without conduct disorder. Unfortunately, theory driven research of adolescents with concomitant alcohol/drug and other mental disorders is lacking, and the specific relapse vulnerabilities and strategies for abstinence for teens with comorbid disorders are unknown. The present proposal is designed to address these two information gaps regarding adolescent alcohol abuse. Specifically, we will 1) follow, at six and eight years our sample of 250 adolescent alcohol abusers (already studied for four years) to determine the long term alcohol and drug use outcome, assess psychiatric and other life problems emerging in this sample, and examine the relationship between clinical course and adult functioning; 2) extend our research of adolescent addiction relapse to the critical area of psychiatric comorbidity to test for differences in rate, process, and circumstances of relapse and examine the applicability of current relapse models to comorbid groups of adolescents; and 3) continue our model building analyses of adolescent functioning across the four follow-up time points and replicate these using the new young adult follow-up data. Major advantages of this project are the less costly opportunity to evaluate young adult functioning of a well-described, consistently followed (four years) sample of 250 adolescent alcohol abusers, extensive research experience with the evaluation of adolescent addiction relapse making successful extension to comorbid psychiatric populations more likely, and the opportunity to explore developmentally sensitive models of alcohol abuse clinical course in an already existing data base.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA007033-18
Application #
6629556
Study Section
Special Emphasis Panel (ZAA1-BB (01))
Program Officer
Lowman, Cherry
Project Start
1986-08-01
Project End
2004-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
18
Fiscal Year
2003
Total Cost
$387,664
Indirect Cost
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Khoddam, Rubin; Worley, Matthew; Browne, Kendall C et al. (2015) Family history density predicts long term substance use outcomes in an adolescent treatment sample. Drug Alcohol Depend 147:235-42
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Hanson, Karen L; Medina, Krista Lisdahl; Padula, Claudia B et al. (2011) Impact of Adolescent Alcohol and Drug Use on Neuropsychological Functioning in Young Adulthood: 10-Year Outcomes. J Child Adolesc Subst Abuse 20:135-154
Hanson, Karen L; Cummins, Kevin; Tapert, Susan F et al. (2011) Changes in neuropsychological functioning over 10 years following adolescent substance abuse treatment. Psychol Addict Behav 25:127-42
Anderson, Kristen G; Ramo, Danielle E; Cummins, Kevin M et al. (2010) Alcohol and drug involvement after adolescent treatment and functioning during emerging adulthood. Drug Alcohol Depend 107:171-81
Anderson, Kristen G; Brown, Sandra A (2010) Middle School Drinking: Who, Where, and When. J Child Adolesc Subst Abuse 20:48-62
Bekman, Nicole M; Cummins, Kevin; Brown, Sandra A (2010) Affective and personality risk and cognitive mediators of initial adolescent alcohol use. J Stud Alcohol Drugs 71:570-80
Ramo, Danielle E; Myers, Mark G; Brown, Sandra A (2010) Self-efficacy mediates the relationship between depression and length of abstinence after treatment among youth but not among adults. Subst Use Misuse 45:2301-22

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