Although tribes differ with regard to the use of alcohol Native Americans, as a group, have the highest alcohol-related death rates of all ethnic groups in the United States. However, how and why alcoholism is more prevalent in some Native American communities remains unclear The overall objective of this research plan is to enhance understanding of the biological risk and protective factors related to alcohol dependence and alcohol-related problems in reservation dwelling Indians indigenous to San Diego county (collectively called Mission Indians). The studies proposed in this application include cross-sectional studies in Mission Indian adults and adolescents, as well as longitudinal studies in Native American children and adolescents. This design allows for the investigation of specific genetic and environmental risk factors existing both prior to alcohol exposure and during the development of drinking patterns. The four aims of the study are: (1) To find identifiable neurobiological factors in Native American youth who progress from alcohol use to abuse, and to dependence;(2) To document whether exposure to high levels of alcohol in adolescence lead to specific and detrimental medical and psychological outcomes;(3) To identify circumstances and mechanisms of behavioral change that lead to either continued alcohol use and disability or remission from alcoholism in this population;and (4) To determine why Native American Mission Indian adults are at such high risk for alcoholism through the identification of specific genetic and environmental factors. These studies have the potential to verify whether Native Americans have any specific biological/genetic, psychosocial or behavioral factors that may help to explain the high risk for alcoholism within the tribes evaluated. The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes.

Public Health Relevance

This study has the potential to provide critical information for understanding how select genetic and environmental factors might interact in the development of alcohol use disorders among Native American men and women living in San Diego County. Ultimately, a better understanding ofthe factors associated with alcohol associated behaviors in Native Americans will contribute important information for understanding the causes of alcohol abuse and dependence and might ultimately aid in the development of efficacious and culturally sensitive prevention and intervention programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA010201-17
Application #
8308357
Study Section
Special Emphasis Panel (NSS)
Program Officer
Matochik, John A
Project Start
1994-09-26
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
17
Fiscal Year
2012
Total Cost
$870,992
Indirect Cost
$412,148
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Otto, Jacqueline M; Gizer, Ian R; Bizon, Chris et al. (2016) Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. Drug Alcohol Depend 167:95-102
Ehlers, C L; Gizer, I R; Bizon, C et al. (2016) Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample. Genes Brain Behav 15:568-77
Norden-Krichmar, Trina M; Gizer, Ian R; Phillips, Evelyn et al. (2015) Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. Twin Res Hum Genet 18:727-37
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Ehlers, Cindy L; Wills, Derek N; Desikan, Anita et al. (2014) Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain. Dev Neurosci 36:175-95
Peng, Qian; Gizer, Ian R; Libiger, Ondrej et al. (2014) Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. Am J Med Genet B Neuropsychiatr Genet 165B:673-83
Norden-Krichmar, Trina M; Gizer, Ian R; Libiger, Ondrej et al. (2014) Correlation analysis of genetic admixture and social identification with body mass index in a Native American community. Am J Hum Biol 26:347-60
Ehlers, Cindy L; Stouffer, Gina M; Gilder, David A (2014) Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans. Alcohol Clin Exp Res 38:2039-47

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