Although tribes differ with regard to the use of alcohol Native Americans, as a group, have the highest alcohol-related death rates of all ethnic groups in the United States. However, how and why alcoholism is more prevalent in some Native American communities remains unclear The overall objective of this research plan is to enhance understanding of the biological risk and protective factors related to alcohol dependence and alcohol-related problems in reservation dwelling Indians indigenous to San Diego county (collectively called Mission Indians). The studies proposed in this application include cross-sectional studies in Mission Indian adults and adolescents, as well as longitudinal studies in Native American children and adolescents. This design allows for the investigation of specific genetic and environmental risk factors existing both prior to alcohol exposure and during the development of drinking patterns. The four aims of the study are: (1) To find identifiable neurobiological factors in Native American youth who progress from alcohol use to abuse, and to dependence;(2) To document whether exposure to high levels of alcohol in adolescence lead to specific and detrimental medical and psychological outcomes;(3) To identify circumstances and mechanisms of behavioral change that lead to either continued alcohol use and disability or remission from alcoholism in this population;and (4) To determine why Native American Mission Indian adults are at such high risk for alcoholism through the identification of specific genetic and environmental factors. These studies have the potential to verify whether Native Americans have any specific biological/genetic, psychosocial or behavioral factors that may help to explain the high risk for alcoholism within the tribes evaluated. The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes.

Public Health Relevance

This study has the potential to provide critical information for understanding how select genetic and environmental factors might interact in the development of alcohol use disorders among Native American men and women living in San Diego County. Ultimately, a better understanding ofthe factors associated with alcohol associated behaviors in Native Americans will contribute important information for understanding the causes of alcohol abuse and dependence and might ultimately aid in the development of efficacious and culturally sensitive prevention and intervention programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA010201-18
Application #
8496647
Study Section
Special Emphasis Panel (NSS)
Program Officer
Matochik, John A
Project Start
1994-09-26
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
18
Fiscal Year
2013
Total Cost
$806,974
Indirect Cost
$381,858
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Melroy-Greif, Whitney E; Wilhelmsen, Kirk C; Yehuda, Rachel et al. (2017) Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations. Twin Res Hum Genet 20:197-207
Peng, Qian; Schork, Nicholas J; Wilhelmsen, Kirk C et al. (2017) Whole genome sequence association and ancestry-informed polygenic profile of EEG alpha in a Native American population. Am J Med Genet B Neuropsychiatr Genet 174:435-450
Peng, Qian; Gizer, Ian R; Wilhelmsen, Kirk C et al. (2017) Associations Between Genomic Variants in Alcohol Dehydrogenase Genes and Alcohol Symptomatology in American Indians and European Americans: Distinctions and Convergence. Alcohol Clin Exp Res 41:1695-1704
Criado, José R; Gilder, David A; Kalafut, Mary A et al. (2016) Cardiovascular disease risks in adult Native and Mexican Americans with a history of alcohol use disorders: association with cardiovascular autonomic control. Clin Auton Res 26:87-95
Ehlers, C L; Gizer, I R; Bizon, C et al. (2016) Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample. Genes Brain Behav 15:568-77
Otto, Jacqueline M; Gizer, Ian R; Bizon, Chris et al. (2016) Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. Drug Alcohol Depend 167:95-102
Gilder, David A; Stouffer, Gina M; Lau, Philip et al. (2016) Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample. Drug Alcohol Depend 161:222-9
Ehlers, Cindy L; Stouffer, Gina M; Corey, Linda et al. (2015) The clinical course of DSM-5 alcohol use disorders in young adult native and Mexican Americans. Am J Addict 24:713-21
Ehlers, Cindy L; Wills, Derek N; Phillips, Evelyn et al. (2015) Low voltage alpha EEG phenotype is associated with reduced amplitudes of alpha event-related oscillations, increased cortical phase synchrony, and a low level of response to alcohol. Int J Psychophysiol 98:65-75
Norden-Krichmar, Trina M; Gizer, Ian R; Phillips, Evelyn et al. (2015) Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. Twin Res Hum Genet 18:727-37

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