Alcohol use disorders exact a substantial toll on America's public health especially with respect to brain structure and its myriad functions. The goal of this proposal is to increase understanding of the nature and potential mechanisms of alcoholism-induced brain injury using advanced magnetic resonance brain imaging that could guide rehabilitation strategies and inform treatment development. Current concepts of diseases of the brain suggest that different diseases affect specific neurocircuitry connecting disparate reaches of the brain. Converging evidence from human in vivo and postmortem studies of chronic alcoholism strongly implicate disruption of frontocerebellar circuitry as a principal contributor to the characteristic pattern of alcoholism-related impairment. Although animal studies have identified the neuroanatomy of cerebrocerebellar circuits relevant to alcoholism, recent human neuroimaging experiments have demonstrated functional cerebrocerebellar circuitry that does not necessarily have a known neuroanatomy. These intrinsic connectivity networks (ICN) can be identified with in vivo functional connectivity MR imaging (fcMRI). In addition to examining the known cerebrocerebellar anatomy, identification of intrinsic neurocircuitry could provide basic science insight into mechanisms underlying selective impairments and fundamental information for developing behavioral or pharmacological therapies and approaches for improving processing efficiency and compensation for associated dysfunction. The goal of this hypothesis-driven proposal is to determine the integrity of cerebrocerebellar ICNs, their functional significance, and the influence of alcohol-induced neuropathology on these networks. The three specific aims are:
Specific Aim 1 : To elucidate the status of intrinsic and activated functional cerebellar networks using resting state fcMRI and task-activated fMRI Specific Aim 2: To determine the impact of alcoholism-induced degradation of the neuroanatomy (identified with MRI and diffusion tensor imaging, DTI) and cerebral blood perfusion (measured with arterial spin labeling, ASL) on task-activated and intrinsic connectivity networks involving frontocerebellar circuitry Specific Aim 3: To examine the motor and cognitive ramifications of intrinsic network status identified with fcMRI.
Alcohol use disorders exact a substantial toll on America's public health especially as it affects the brain and its many functions. The goal of this proposal is to increase the understanding of the nature and potential biological mechanisms of alcoholism-induced brain injury, which may well contribute to difficulties in achieving and maintaining sobriety. Advanced magnetic resonance brain imaging used to specify where alcoholic injury occurs in the brain and how injury impairs function should guide insights for rehabilitation strategies and treatment development.
|Jung, Young-Chul; Schulte, Tilman; Müller-Oehring, Eva M et al. (2014) Compromised frontocerebellar circuitry contributes to nonplanning impulsivity in recovering alcoholics. Psychopharmacology (Berl) 231:4443-53|
|Le Berre, Anne-Pascale; Pitel, Anne-Lise; Chanraud, Sandra et al. (2014) Chronic alcohol consumption and its effect on nodes of frontocerebellar and limbic circuitry: comparison of effects in France and the United States. Hum Brain Mapp 35:4635-53|
|Pfefferbaum, Adolf; Rohlfing, Torsten; Rosenbloom, Margaret J et al. (2013) Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI. Neuroimage 65:176-93|
|Muller-Oehring, Eva M; Schulte, Tilman; Rohlfing, Torsten et al. (2013) Visual search and the aging brain: discerning the effects of age-related brain volume shrinkage on alertness, feature binding, and attentional control. Neuropsychology 27:48-59|
|Sullivan, Edith V; Muller-Oehring, Eva; Pitel, Anne-Lise et al. (2013) A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. Biol Psychiatry 74:547-55|
|Pitel, Anne-Lise; Chanraud, Sandra; Muller-Oehring, Eva M et al. (2013) Modulation of limbic-cerebellar functional connectivity enables alcoholics to recognize who is who. Brain Struct Funct 218:683-95|
|Schulte, Tilman; Muller-Oehring, Eva M; Sullivan, Edith V et al. (2012) Synchrony of corticostriatal-midbrain activation enables normal inhibitory control and conflict processing in recovering alcoholic men. Biol Psychiatry 71:269-78|
|Pfefferbaum, Adolf; Chanraud, Sandra; Pitel, Anne-Lise et al. (2011) Cerebral blood flow in posterior cortical nodes of the default mode network decreases with task engagement but remains higher than in most brain regions. Cereb Cortex 21:233-44|
|Pitel, Anne-Lise; Zahr, Natalie M; Jackson, Karen et al. (2011) Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome. Neuropsychopharmacology 36:580-8|
|Muller-Oehring, Eva M; Schulte, Tilman; Rosenbloom, Margaret J et al. (2010) Callosal degradation in HIV-1 infection predicts hierarchical perception: a DTI study. Neuropsychologia 48:1133-43|
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