This competing renewal application requests funding for Years 11-15 to continue study of the onset, course, causes, and consequences of alcohol use and alcohol use disorders in The Pittsburgh ADHD Longitudinal Study (PALS). In the PALS, 364 children with ADHD (probands) were ascertained in their elementary school-aged years following their participation in the ADHD Summer Treatment Program at WPIC, University of Pittsburgh. This is the largest study of its kind: rigorously diagnosed ADHD in childhood, detailed comprehensive childhood data (including standardized and objective data), and detailed annual follow-up assessments of domains theoretically related to the development of alcohol abuse and alcohol dependence (e.g., family history of alcoholism;alcohol expectancies). A nonADHD demographically similar group of participants (n=240) was recruited during the first follow-up of the probands between grant years 1 and 5 when participant ages ranged from 11 to 25. Using a cohort sequential design, all participants have been followed annually since recruitment into the PALS;retention is over 90% and a multiple reporter approach has been adopted throughout. A sampling of findings includes: 1) a higher risk for heavy drinking and AUD in proband adolescents;2) absence of proband-control differences for AUD at 18-25 yrs when controls are also drinking heavily;3) positive association between duration of lifetime stimulant treatment and early adulthood binge drinking, 4) weak associations between childhood conduct problems and later drinking outcomes but strong concurrent associations, supporting an ADHD?conduct?AUD pathway, and 5) moderating influence of parental monitoring on ADHD risk for longitudinal growth in adolescent drinking frequency. Continued follow-up (annual to age 25, age-targeted periodic assessments thereafter) is requested to determine whether early heavy drinking patterns persist through the twenties when desistance is the U.S. norm, to determine whether new cases of AUD develop in the mid-to-late 20s, and to study the putative causal mechanisms underlying these AUD developments and consequences in early adulthood.

Public Health Relevance

This is a large long-term study of alcoholism in people who were diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) in childhood. This study will help explain why children with ADHD are at risk of alcoholism, including what factors contribute to the risk and what factors decrease the risk. ADHD is one of the most frequently diagnosed mental health problems of children in the United States;alcoholism risk in these individuals carries large direct and indirect costs to society. This study will provide information to improve prevention as well as treatments for alcohol problems in this large group of high risk children in the U.S.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AA011873-15
Application #
8320396
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Ruffin, Beverly
Project Start
1998-09-07
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
15
Fiscal Year
2012
Total Cost
$759,445
Indirect Cost
$181,816
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
O'Connor, Briannon C; Fabiano, Gregory A; Waschbusch, Daniel A et al. (2014) Effects of a summer treatment program on functional sports outcomes in young children with ADHD. J Abnorm Child Psychol 42:1005-17
Sibley, Margaret H; Pelham, William E; Molina, Brooke S G et al. (2014) The role of early childhood ADHD and subsequent CD in the initiation and escalation of adolescent cigarette, alcohol, and marijuana use. J Abnorm Psychol 123:362-74
Pedersen, Sarah L; Harty, Seth C; Pelham, William E et al. (2014) Differential associations between alcohol expectancies and adolescent alcohol use as a function of childhood ADHD. J Stud Alcohol Drugs 75:145-52
Kuriyan, Aparajita B; Pelham Jr, William E; Molina, Brooke S G et al. (2014) Concordance between parent and physician medication histories for children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 24:269-74
Molina, Brooke S G; Pelham Jr, William E (2014) Attention-deficit/hyperactivity disorder and risk of substance use disorder: developmental considerations, potential pathways, and opportunities for research. Annu Rev Clin Psychol 10:607-39
Molina, Brooke S G; Walther, Christine A P; Cheong, Jeewon et al. (2014) Heavy alcohol use in early adulthood as a function of childhood ADHD: developmentally specific mediation by social impairment and delinquency. Exp Clin Psychopharmacol 22:110-21
Babinski, Dara E; Sibley, Margaret H; Ross, J Megan et al. (2013) The effects of single versus mixed gender treatment for adolescent girls with ADHD. J Clin Child Adolesc Psychol 42:243-50
Sibley, Margaret H; Pelham Jr, William E; Molina, Brooke S G et al. (2012) Diagnosing ADHD in adolescence. J Consult Clin Psychol 80:139-50
Pelham, William E; Waxmonsky, James G; Schentag, Jerome et al. (2011) Efficacy of a methylphenidate transdermal system versus t.i.d. methylphenidate in a laboratory setting. J Atten Disord 15:28-35
Babinski, Dara E; Pelham Jr, William E; Molina, Brooke S G et al. (2011) Women with Childhood ADHD: Comparisons by Diagnostic Group and Gender. J Psychopathol Behav Assess 33:420-429

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