Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AA012054-06
Application #
6761666
Study Section
Special Emphasis Panel (NSS)
Program Officer
Twombly, Dennis
Project Start
1999-07-01
Project End
2009-03-31
Budget Start
2004-05-01
Budget End
2005-03-31
Support Year
6
Fiscal Year
2004
Total Cost
$266,016
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Wynne, P M; Puig, S I; Martin, G E et al. (2009) Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system. J Pharmacol Exp Ther 329:978-86
Martin, Gilles; O'Connell, Robert J; Pietrzykowski, Andrzej Z et al. (2008) Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol 93:908-18
Yuan, Chunbo; O'Connell, Robert J; Wilson, Andrew et al. (2008) Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment. J Biol Chem 283:5090-8
Feinberg-Zadek, Paula L; Martin, Gilles; Treistman, Steven N (2008) BK channel subunit composition modulates molecular tolerance to ethanol. Alcohol Clin Exp Res 32:1207-16
Yuan, Chunbo; O'Connell, Robert J; Jacob, Robert F et al. (2007) Regulation of the gating of BKCa channel by lipid bilayer thickness. J Biol Chem 282:7276-86
O'Connell, Robert J; Yuan, Chunbo; Johnston, Linda J et al. (2006) Gating and conductance changes in BK(Ca) channels in bilayers are reciprocal. J Membr Biol 213:143-53
Yuan, Chunbo; O'Connell, Robert J; Feinberg-Zadek, Paula L et al. (2004) Bilayer thickness modulates the conductance of the BK channel in model membranes. Biophys J 86:3620-33
Levine, John B; Martin, Gilles; Wilson, Andrew et al. (2003) Clozapine inhibits isolated N-methyl-D-aspartate receptors expressed in xenopus oocytes in a subunit specific manner. Neurosci Lett 346:125-8