In the Victoria Longitudinal Study (VLS), we conduct a series of cross-sectional and longitudinal studies pertaining to the description and explanation of changes in cognitive performance in late adulthood. The research derives from the perspective that the magnitude and rate of late-life changes in memory performance depend substantially on individual differences in such underlying factors as (a) cognitive ability and resource components, (b) metacognitive and compensatory knowledge and implementation, (c) selected health,;biomedical, sensory, neuropsychological, and physiological conditions, and (d) lifestyle, activity, and demographic background indicators. The principal objective is to continue an ongoing large-scale longitudinal investigation, thereby enhancing a unique and increasingly rich data set, on human aging. _ """""""";j The VLS is designed as a longitudinal sequential study. Three independent samples of 55-85-year old adults are recruited at six^year intervals. Each sample is re-tested at three-year longitudinal intervals.. To date, Sarnpre:lt(originai n^484;average return rateover 70%) has been tested five times over 12years (start years 1986;1989,19i92,. 1995,1999). The sixth wave occurs in 2002. Sample 2 (original n=530; average return rate over 80%) has been tested three times over six years (start years 1993,1996,1999). The fourth (late 2002) and fifth waves (2005) occur in this research period. Sample 3 (expected n=530) is presently being tested (current n=300). The second wave begins in 2004. Several comparison samples have been developed in recent years. Approximately 10 hours of data are collected per participant at each occasion. In sum, the proposed research is designed to examine the extent and trajectories of aging-related cognitive and memory changes, as influenced by (a) patterns of differential decline in theoretically derived classes of influencjng/cognitive components, and (b) conditions representing selected physiological, ?: ^ health, and lifestyle characteristics. - .

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG008235-21
Application #
8112660
Study Section
Special Emphasis Panel (NSS)
Program Officer
King, Jonathan W
Project Start
1989-08-01
Project End
2013-07-31
Budget Start
2011-08-15
Budget End
2013-07-31
Support Year
21
Fiscal Year
2011
Total Cost
$206,468
Indirect Cost
Name
University of Alberta
Department
Type
DUNS #
208095844
City
Edmonton
State
AB
Country
Canada
Zip Code
T6 2-E1
de Frias, Cindy M; Dixon, Roger A (2014) Lifestyle engagement affects cognitive status differences and trajectories on executive functions in older adults. Arch Clin Neuropsychol 29:16-25
McFall, G Peggy; Wiebe, Sandra A; Vergote, David et al. (2013) IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults. Neurobiol Aging 34:2208-16
de Frias, Cindy M; Dixon, Roger A; Camicioli, Richard (2012) Neurocognitive speed and inconsistency in Parkinson's disease with and without incipient dementia: an 18-month prospective cohort study. J Int Neuropsychol Soc 18:764-72
Small, Brent J; Dixon, Roger A; McArdle, John J et al. (2012) Do changes in lifestyle engagement moderate cognitive decline in normal aging? Evidence from the Victoria Longitudinal Study. Neuropsychology 26:144-55
Dolcos, Sanda; MacDonald, Stuart W S; Braslavsky, Anna et al. (2012) Mild cognitive impairment is associated with selected functional markers: integrating concurrent, longitudinal, and stability effects. Neuropsychology 26:209-223
Mitchell, Meghan B; Cimino, Cynthia R; Benitez, Andreana et al. (2012) Cognitively Stimulating Activities: Effects on Cognition across Four Studies with up to 21 Years of Longitudinal Data. J Aging Res 2012:461592
Brown, Cassandra L; Gibbons, Laura E; Kennison, Robert F et al. (2012) Social activity and cognitive functioning over time: a coordinated analysis of four longitudinal studies. J Aging Res 2012:287438
Zheng, Jiamin; Dixon, Roger A; Li, Liang (2012) Development of isotope labeling LC-MS for human salivary metabolomics and application to profiling metabolome changes associated with mild cognitive impairment. Anal Chem 84:10802-11
Lindwall, Magnus; Cimino, Cynthia R; Gibbons, Laura E et al. (2012) Dynamic associations of change in physical activity and change in cognitive function: coordinated analyses of four longitudinal studies. J Aging Res 2012:493598
Small, Brent J; Dixon, Roger A; McArdle, John J (2011) Tracking cognition-health changes from 55 to 95 years of age. J Gerontol B Psychol Sci Soc Sci 66 Suppl 1:i153-61

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