Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG009909-22
Application #
8286195
Study Section
Special Emphasis Panel (NSS)
Program Officer
Velazquez, Jose M
Project Start
1990-09-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
22
Fiscal Year
2012
Total Cost
$613,438
Indirect Cost
$297,233
Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945
Hernandez-Segura, Alejandra; de Jong, Tristan V; Melov, Simon et al. (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol 27:2652-2660.e4
Baar, Marjolein P; Brandt, Renata M C; Putavet, Diana A et al. (2017) Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell 169:132-147.e16
Perrott, Kevin M; Wiley, Christopher D; Desprez, Pierre-Yves et al. (2017) Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience 39:161-173
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Jeon, Ok Hee; Kim, Chaekyu; Laberge, Remi-Martin et al. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775-781
Demaria, Marco; O'Leary, Monique N; Chang, Jianhui et al. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov 7:165-176
Wiley, Christopher D; Campisi, Judith (2016) From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence. Cell Metab 23:1013-1021
Campisi, Judith (2016) Cellular Senescence and Lung Function during Aging. Yin and Yang. Ann Am Thorac Soc 13:S402-S406
Chang, Jianhui; Wang, Yingying; Shao, Lijian et al. (2016) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med 22:78-83
Wiley, Christopher D; Velarde, Michael C; Lecot, Pacome et al. (2016) Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab 23:303-14

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