Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG009909-22
Application #
8286195
Study Section
Special Emphasis Panel (NSS)
Program Officer
Velazquez, Jose M
Project Start
1990-09-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
22
Fiscal Year
2012
Total Cost
$613,438
Indirect Cost
$297,233
Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945
Tomé, María; Sepúlveda, Juan Carlos; Delgado, Mario et al. (2014) miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity. Stem Cells 32:2229-44
Campisi, Judith; Robert, Ladislas (2014) Cell senescence: role in aging and age-related diseases. Interdiscip Top Gerontol 39:45-61
Campisi, Judith (2014) Cell biology: The beginning of the end. Nature 505:35-6
Sepúlveda, Juan Carlos; Tomé, María; Fernández, María Eugenia et al. (2014) Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells 32:1865-77
Laberge, R-M; Adler, D; DeMaria, M et al. (2013) Mitochondrial DNA damage induces apoptosis in senescent cells. Cell Death Dis 4:e727
Davalos, Albert R; Kawahara, Misako; Malhotra, Gautam K et al. (2013) p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 201:613-29
Freund, Adam; Laberge, Remi-Martin; Demaria, Marco et al. (2012) Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell 23:2066-75
Rodier, Francis; Munoz, Denise P; Teachenor, Robert et al. (2011) DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci 124:68-81
Campisi, Judith; Andersen, Julie K; Kapahi, Pankaj et al. (2011) Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol 21:354-9
Coppe, Jean-Philippe; Rodier, Francis; Patil, Christopher K et al. (2011) Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem 286:36396-403

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