Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG009909-25
Application #
8882200
Study Section
Special Emphasis Panel (NSS)
Program Officer
Velazquez, Jose M
Project Start
1990-09-01
Project End
2017-05-31
Budget Start
2015-06-01
Budget End
2017-05-31
Support Year
25
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945
Wiley, Christopher D; Schaum, Nicholas; Alimirah, Fatouma et al. (2018) Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. Sci Rep 8:2410
Jeon, Ok Hee; David, Nathaniel; Campisi, Judith et al. (2018) Senescent cells and osteoarthritis: a painful connection. J Clin Invest 128:1229-1237
Perrott, Kevin M; Wiley, Christopher D; Desprez, Pierre-Yves et al. (2017) Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience 39:161-173
Jeon, Ok Hee; Kim, Chaekyu; Laberge, Remi-Martin et al. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775-781
Wiley, Christopher D; Flynn, James M; Morrissey, Christapher et al. (2017) Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16:1043-1050
Baar, Marjolein P; Brandt, Renata M C; Putavet, Diana A et al. (2017) Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell 169:132-147.e16
Demaria, Marco; O'Leary, Monique N; Chang, Jianhui et al. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov 7:165-176
Wiley, Christopher D; Campisi, Judith (2016) From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence. Cell Metab 23:1013-1021
Kruiswijk, F; Hasenfuss, S C; Sivapatham, R et al. (2016) Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling. Oncogene 35:2166-77
Campisi, Judith (2016) Cellular Senescence and Lung Function during Aging. Yin and Yang. Ann Am Thorac Soc 13 Suppl 5:S402-S406

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