Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AG011385-14
Application #
7216114
Study Section
Special Emphasis Panel (NSS)
Program Officer
Snyder, Stephen D
Project Start
1992-09-01
Project End
2012-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
14
Fiscal Year
2007
Total Cost
$490,830
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
099992430
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Spencer, Brian; Kim, Changyoun; Gonzalez, Tania et al. (2016) ?-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease. Hum Mol Genet 25:1100-15
Suberbielle, Elsa; Djukic, Biljana; Evans, Mark et al. (2015) DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun 6:8897
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Suberbielle, Elsa; Sanchez, Pascal E; Kravitz, Alexxai V et al. (2013) Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-?. Nat Neurosci 16:613-21
Sanchez, Pascal E; Zhu, Lei; Verret, Laure et al. (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A 109:E2895-903
Bae, Eun-Jin; Lee, He-Jin; Rockenstein, Edward et al. (2012) Antibody-aided clearance of extracellular ?-synuclein prevents cell-to-cell aggregate transmission. J Neurosci 32:13454-69

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