Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG012279-17
Application #
8228089
Study Section
Special Emphasis Panel (NSS)
Program Officer
Fuldner, Rebecca A
Project Start
1995-09-15
Project End
2016-01-31
Budget Start
2012-02-15
Budget End
2013-01-31
Support Year
17
Fiscal Year
2012
Total Cost
$342,627
Indirect Cost
$137,627
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Woods, Dori C; Khrapko, Konstantin; Tilly, Jonathan L (2018) Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos. Genes (Basel) 9:
Truman, Alisha M; Tilly, Jonathan L; Woods, Dori C (2017) Ovarian regeneration: The potential for stem cell contribution in the postnatal ovary to sustained endocrine function. Mol Cell Endocrinol 445:74-84
Safdar, Adeel; Annis, Sofia; Kraytsberg, Yevgenya et al. (2016) Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1?, p53, and DNA damage. A hypothesis. Curr Opin Genet Dev 38:127-132
Woods, Dori C; Tilly, Jonathan L (2015) Autologous Germline Mitochondrial Energy Transfer (AUGMENT) in Human Assisted Reproduction. Semin Reprod Med 33:410-21
Park, Eun-Sil; Tilly, Jonathan L (2015) Use of DEAD-box polypeptide-4 (Ddx4) gene promoter-driven fluorescent reporter mice to identify mitotically active germ cells in post-natal mouse ovaries. Mol Hum Reprod 21:58-65
Woods, Dori C; Tilly, Jonathan L (2015) Woods and Tilly reply. Nat Med 21:1118-21
Park, Eun-Sil; Woods, Dori C; Tilly, Jonathan L (2013) Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling. Fertil Steril 100:1468-75
Tilly, Jonathan L; Sinclair, David A (2013) Germline energetics, aging, and female infertility. Cell Metab 17:838-50
Woods, Dori C; Tilly, Jonathan L (2013) An evolutionary perspective on adult female germline stem cell function from flies to humans. Semin Reprod Med 31:24-32
Woods, Dori C; White, Yvonne A R; Niikura, Yuichi et al. (2013) Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo. Reprod Sci 20:524-35

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