Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG012279-17
Application #
8228089
Study Section
Special Emphasis Panel (NSS)
Program Officer
Fuldner, Rebecca A
Project Start
1995-09-15
Project End
2016-01-31
Budget Start
2012-02-15
Budget End
2013-01-31
Support Year
17
Fiscal Year
2012
Total Cost
$342,627
Indirect Cost
$137,627
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Park, Eun-Sil; Tilly, Jonathan L (2015) Use of DEAD-box polypeptide-4 (Ddx4) gene promoter-driven fluorescent reporter mice to identify mitotically active germ cells in post-natal mouse ovaries. Mol Hum Reprod 21:58-65
Imudia, Anthony N; Wang, Ning; Tanaka, Yoshihiro et al. (2013) Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity. Fertil Steril 100:1451-8
Woods, Dori C; Tilly, Jonathan L (2013) Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc 8:966-88
Woods, Dori C; Tilly, Jonathan L (2013) An evolutionary perspective on adult female germline stem cell function from flies to humans. Semin Reprod Med 31:24-32
Woods, Dori C; White, Yvonne A R; Tilly, Jonathan L (2013) Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future. Reprod Sci 20:7-15
Park, Eun-Sil; Woods, Dori C; Tilly, Jonathan L (2013) Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling. Fertil Steril 100:1468-75
Woods, Dori C; White, Yvonne A R; Niikura, Yuichi et al. (2013) Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo. Reprod Sci 20:524-35
White, Yvonne A R; Woods, Dori C; Takai, Yasushi et al. (2012) Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med 18:413-21
Selesniemi, Kaisa; Lee, Ho-Joon; Muhlhauser, Ailene et al. (2011) Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc Natl Acad Sci U S A 108:12319-24
Wang, Ning; Tilly, Jonathan L (2010) Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. Cell Cycle 9:339-49

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