of observed states of the network, that is normally tightly coupled with corresponding relationships in physical space. Thus, under constant conditions, an external observer can reconstruct a rat's position from the collective firing pattern (e.g., Wilson and McNaughton, 1993;Zhang et al., 1998). The expression, storage, and retrieval of these neuronal 'maps'provides an excellent forum in which to explore the extent to which age-related alterations in neural system level dynamics can be linked at lower levels to changes in cellular physiology, and at higher levels to changes in the behavioral expression of memory 16

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG012609-20
Application #
8490255
Study Section
Special Emphasis Panel (NSS)
Program Officer
Wagster, Molly V
Project Start
1994-04-15
Project End
2014-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$276,854
Indirect Cost
$92,507
Name
University of Arizona
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Burke, Sara N; Maurer, Andrew P; Nematollahi, Saman et al. (2014) Advanced age dissociates dual functions of the perirhinal cortex. J Neurosci 34:467-80
Samson, Rachel D; Venkatesh, Anu; Patel, Dhara H et al. (2014) Enhanced performance of aged rats in contingency degradation and instrumental extinction tasks. Behav Neurosci 128:122-33
Maurer, Andrew P; Lester, Adam W; Burke, Sara N et al. (2014) Back to the future: preserved hippocampal network activity during reverse ambulation. J Neurosci 34:15022-31
Burke, Sara N; Thome, Alex; Plange, Kojo et al. (2014) Orbitofrontal cortex volume in area 11/13 predicts reward devaluation, but not reversal learning performance, in young and aged monkeys. J Neurosci 34:9905-16
Schimanski, Lesley A; Lipa, Peter; Barnes, Carol A (2013) Tracking the course of hippocampal representations during learning: when is the map required? J Neurosci 33:3094-106
Samson, Rachel D; Barnes, Carol A (2013) Impact of aging brain circuits on cognition. Eur J Neurosci 37:1903-15
Hartzell, Andrea L; Burke, Sara N; Hoang, Lan T et al. (2013) Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age. J Neurosci 33:3424-33
Maurer, Andrew P; Burke, Sara N; Lipa, Peter et al. (2012) Greater running speeds result in altered hippocampal phase sequence dynamics. Hippocampus 22:737-47
Burke, Sara N; Maurer, Andrew P; Nematollahi, Saman et al. (2011) The influence of objects on place field expression and size in distal hippocampal CA1. Hippocampus 21:783-801
Henriksen, Espen J; Colgin, Laura L; Barnes, Carol A et al. (2010) Spatial representation along the proximodistal axis of CA1. Neuron 68:127-37

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