Verification was completed by DMAPS/PSB PAGE(S) . .. ^. ^ was not included in Original Application Package Date ihijlO Initials (X-Qf^ Program Director/Principal Investigator (Last, First, Middle): MasNah, ENezer FROM THROUGH DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY 07/1/11 06/30/12 List PERSONNEL (Applicant organization only) Use Gal, Acad, or Summer to Enter Months Devoted to Project Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits ROLE ON Cal. Acad. Summer INST.BASE SALARY FRINGE NAME PROJECT Mnths Mnths Mnths SALARY REQUESTED BENEFITS TOTAL Eliezer Masliah PD/PI 2.4 199,700 39,940 8,787 48,727 Ed Rockenstein SRA 4.8 63,816 25,527 7,658 33,185 Michael Mante SRA 4.8 44,856 17,942 8,971 26,914 Anthony Adame SRA 4.8 46,683 18,673 5,602 24,275 PostDoc Paula DesPlats 6.0 54,495 27,248 10,899 38,147 Researcher Leslie Crews GSR 2.4 58,860 11,772 2,943 14,715 SUBTOTALS 141,102 44,860 185,962 CONSULTANT COSTS EQUIPMENT (Itemize) SUPPLIES (Itemize by category) Immunocytochemical $20,000 Surgical $2,268 Biochemical $15,000 Molecular Biology $5,000 General Lab Supplies $607 42,875 TRAVEL INPATIENT CARE COSTS OUTPATIENT CARE COSTS ALTERATIONS AND RENOVATIONS (Itemize by category) OTHER EXPENSES (Itemize by category) Breeding and Animal Maintenance $18,579 NGN/Communication $2,585 21,163 CONSORTIUM/CONTRACTUAL COSTS DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a. Face Page) $ 250,000 CONSORTIUM/CONTRACTUAL COSTS FACILITIES AND ADMINISTRATIVE COSTS TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD $ 250,000 PHS 398 (Rev. 6/09) Page_ Form Page 4

National Institute of Health (NIH)
National Institute on Aging (NIA)
Method to Extend Research in Time (MERIT) Award (R37)
Project #
Application #
Study Section
Special Emphasis Panel (NSS)
Program Officer
Refolo, Lorenzo
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Gillman, Alan L; Lee, Joon; Ramachandran, Srinivasan et al. (2016) Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine 12:2331-2340
Kratter, Ian H; Zahed, Hengameh; Lau, Alice et al. (2016) Serine 421 regulates mutant huntingtin toxicity and clearance in mice. J Clin Invest 126:3585-97
Rockenstein, Edward; Clarke, Jennifer; Viel, Catherine et al. (2016) Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease. Hum Mol Genet 25:2645-2660
Kim, Changyoun; Lee, He-Jin; Masliah, Eliezer et al. (2016) Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2. Exp Neurobiol 25:113-9
Price, Diana L; Rockenstein, Edward; Mante, Michael et al. (2016) Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Sci Rep 6:29523
Fields, Jerel Adam; Serger, Elisabeth; Campos, Sofia et al. (2016) HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis 86:154-69
Valera, Elvira; Spencer, Brian; Masliah, Eliezer (2016) Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders. Neurotherapeutics 13:179-89
Kim, Eunhee; Wang, Bin; Sastry, Namratha et al. (2016) NEDD4-mediated HSF1 degradation underlies α-synucleinopathy. Hum Mol Genet 25:211-22
de Wilde, Martijn C; Overk, Cassia R; Sijben, John W et al. (2016) Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability. Alzheimers Dement 12:633-44
Kim, Changyoun; Lv, Guohua; Lee, Jun Sung et al. (2016) Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril. Sci Rep 6:30891

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