Verification was completed by DMAPS/PSB PAGE(S) . .. ^. ^ was not included in Original Application Package Date ihijlO Initials (X-Qf^ Program Director/Principal Investigator (Last, First, Middle): MasNah, ENezer FROM THROUGH DETAILED BUDGET FOR INITIAL BUDGET PERIOD DIRECT COSTS ONLY 07/1/11 06/30/12 List PERSONNEL (Applicant organization only) Use Gal, Acad, or Summer to Enter Months Devoted to Project Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe Benefits ROLE ON Cal. Acad. Summer INST.BASE SALARY FRINGE NAME PROJECT Mnths Mnths Mnths SALARY REQUESTED BENEFITS TOTAL Eliezer Masliah PD/PI 2.4 199,700 39,940 8,787 48,727 Ed Rockenstein SRA 4.8 63,816 25,527 7,658 33,185 Michael Mante SRA 4.8 44,856 17,942 8,971 26,914 Anthony Adame SRA 4.8 46,683 18,673 5,602 24,275 PostDoc Paula DesPlats 6.0 54,495 27,248 10,899 38,147 Researcher Leslie Crews GSR 2.4 58,860 11,772 2,943 14,715 SUBTOTALS 141,102 44,860 185,962 CONSULTANT COSTS EQUIPMENT (Itemize) SUPPLIES (Itemize by category) Immunocytochemical $20,000 Surgical $2,268 Biochemical $15,000 Molecular Biology $5,000 General Lab Supplies $607 42,875 TRAVEL INPATIENT CARE COSTS OUTPATIENT CARE COSTS ALTERATIONS AND RENOVATIONS (Itemize by category) OTHER EXPENSES (Itemize by category) Breeding and Animal Maintenance $18,579 NGN/Communication $2,585 21,163 CONSORTIUM/CONTRACTUAL COSTS DIRECT COSTS SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a. Face Page) $ 250,000 CONSORTIUM/CONTRACTUAL COSTS FACILITIES AND ADMINISTRATIVE COSTS TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD $ 250,000 PHS 398 (Rev. 6/09) Page_ Form Page 4

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG018440-12
Application #
8289423
Study Section
Special Emphasis Panel (NSS)
Program Officer
Refolo, Lorenzo
Project Start
2000-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
12
Fiscal Year
2012
Total Cost
$309,203
Indirect Cost
$109,717
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Chen, Xu-Qiao; Fang, Fang; Florio, Jazmin B et al. (2018) T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic 19:840-853
Valera, Elvira; Masliah, Eliezer (2018) The neuropathology of multiple system atrophy and its therapeutic implications. Auton Neurosci 211:1-6
Spencer, Brian; Br├╝schweiler, Sven; Sealey-Cardona, Marco et al. (2018) Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathol 136:69-87
Adamowicz, David H; Roy, Subhojit; Salmon, David P et al. (2017) Hippocampal ?-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci 37:1675-1684
Valera, Elvira; Spencer, Brian; Fields, Jerel A et al. (2017) Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun 5:2
El-Agnaf, Omar; Overk, Cassia; Rockenstein, Edward et al. (2017) Differential effects of immunotherapy with antibodies targeting ?-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis 104:85-96
Overk, Cassia; Masliah, Eliezer (2017) Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease. Alzheimers Dement 13:183-185
Ihse, Elisabet; Yamakado, Hodaka; van Wijk, Xander M et al. (2017) Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep 7:9008
Ngolab, Jennifer; Trinh, Ivy; Rockenstein, Edward et al. (2017) Brain-derived exosomes from dementia with Lewy bodies propagate ?-synuclein pathology. Acta Neuropathol Commun 5:46
Valera, Elvira; Spencer, Brian; Mott, Jennifer et al. (2017) MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Front Mol Neurosci 10:329

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