Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG025805-10
Application #
8521029
Study Section
Special Emphasis Panel (NSS)
Program Officer
Fuldner, Rebecca A
Project Start
2005-09-01
Project End
2015-05-31
Budget Start
2013-09-01
Budget End
2014-05-31
Support Year
10
Fiscal Year
2013
Total Cost
$426,815
Indirect Cost
$167,353
Name
University of Massachusetts Medical School Worcester
Department
Pathology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Zhang, Wenliang; Brahmakshatriya, Vinayak; Swain, Susan L (2014) CD4 T cell defects in the aged: causes, consequences and strategies to circumvent. Exp Gerontol 54:67-70
McKinstry, K Kai; Dutton, Richard W; Swain, Susan L et al. (2013) Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful. Arch Immunol Ther Exp (Warsz) 61:341-53
Swain, Susan L; Blomberg, Bonnie B (2013) Immune senescence: new insights into defects but continued mystery of root causes. Curr Opin Immunol 25:495-7
Haynes, Laura; Swain, Susan L (2012) Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol :
Swain, Susan L; McKinstry, K Kai; Strutt, Tara M (2012) Expanding roles for CD4ýýý T cells in immunity to viruses. Nat Rev Immunol 12:136-48
Torrado, Egidio; Robinson, Richard T; Cooper, Andrea M (2011) Cellular response to mycobacteria: balancing protection and pathology. Trends Immunol 32:66-72
McKinstry, K K; Strutt, T M; Swain, S L (2011) Hallmarks of CD4 T cell immunity against influenza. J Intern Med 269:507-18
Strutt, Tara M; McKinstry, K Kai; Swain, Susan L (2011) Control of innate immunity by memory CD4 T cells. Adv Exp Med Biol 780:57-68
Strutt, Tara M; McKinstry, K Kai; Dibble, John P et al. (2010) Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 16:558-64, 1p following 564
Jones, Stephen C; Brahmakshatriya, Vinayak; Huston, Gail et al. (2010) TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol 185:6783-94

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