Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI012184-27
Application #
6407950
Study Section
Special Emphasis Panel (NSS)
Program Officer
Kehn, Patricia J
Project Start
1977-07-01
Project End
2007-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
27
Fiscal Year
2002
Total Cost
$469,392
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Cantor, Harvey; Shinohara, Mari L (2009) Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol 9:137-41
Werneck, Miriam B F; Lugo-Villarino, Geanncarlo; Hwang, Eun Sook et al. (2008) T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol 180:8004-10
Shinohara, Mari L; Kim, Hye-Jung; Kim, June-Ho et al. (2008) Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. Proc Natl Acad Sci U S A 105:7235-9
Shinohara, Mari L; Kim, June-Ho; Garcia, Virgilio A et al. (2008) Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29:68-78
Lu, Linrong; Werneck, Miriam B F; Cantor, Harvey (2006) The immunoregulatory effects of Qa-1. Immunol Rev 212:51-9
Shinohara, Mari L; Lu, Linrong; Bu, Jing et al. (2006) Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol 7:498-506
Shinohara, Mari L; Jansson, Marianne; Hwang, Eun Sook et al. (2005) T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A 102:17101-6
Jacobs, Jonathan P; Pettit, Allison R; Shinohara, Mari L et al. (2004) Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum 50:2685-94
McCarty, Nami; Shinohara, Mari L; Lu, Linrong et al. (2004) Detailed analysis of gene expression during development of T cell lineages in the thymus. Proc Natl Acad Sci U S A 101:9339-44
Jansson, Marianne; Panoutsakopoulou, Vily; Baker, Jessica et al. (2002) Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J Immunol 168:2096-9

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