Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI020038-20
Application #
6631693
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mallia, Conrad M
Project Start
1984-01-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
20
Fiscal Year
2003
Total Cost
$414,037
Indirect Cost
Name
University of California San Francisco
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Proekt, Irina; Miller, Corey N; Jeanne, Marion et al. (2016) LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest 126:3758-3771
Gross, Andrew J; Proekt, Irina; DeFranco, Anthony L (2011) Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol 41:3645-55
Gupta, Neetu; Wollscheid, Bernd; Watts, Julian D et al. (2006) Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol 7:625-33
Nishiya, Tadashi; Kajita, Emi; Miwa, Soichi et al. (2005) TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem 280:37107-17
Tian, Maoxin Tim; Gonzalez, Gabriel; Scheer, Barbara et al. (2005) Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 106:2105-12
Nishiya, Tadashi; DeFranco, Anthony L (2004) Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 279:19008-17
Gupta, Neetu; DeFranco, Anthony L (2003) Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell 14:432-44
Richards, J D; Dave, S H; Chou, C H et al. (2001) Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J Immunol 166:3855-64
Tian, M T; Chou, C H; DeFranco, A L (2001) Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells. Int Immunol 13:581-92
Fitzer-Attas, C J; Lowry, M; Crowley, M T et al. (2000) Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med 191:669-82

Showing the most recent 10 out of 44 publications