Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AI020729-10S1
Application #
3481134
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1983-09-15
Project End
1997-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Manuel, Edwin R; Yeh, Wendy W; Seaman, Michael S et al. (2009) Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus. J Virol 83:10028-35
Kim, Eun-Young; Veazey, Ronald S; Zahn, Roland et al. (2008) Contribution of CD8+ T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in Simian immunodeficiency virus-infected rhesus monkeys. J Virol 82:5631-5
Permar, Sallie R; Rao, Srinivas S; Sun, Yue et al. (2007) Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. J Infect Dis 196:1784-93
Hasegawa, Atsuhiko; Moriya, Chikaya; Liu, Huining et al. (2007) Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance. J Immunol 178:3409-17
Manuel, Edwin R; Charini, William A; Sen, Pritha et al. (2006) Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses. J Virol 80:12032-40
Newberg, Michael H; McEvers, Kimberly J; Gorgone, Darci A et al. (2006) Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys. J Immunol 176:319-28
Margolin, David H; Saunders, Erika H; Bronfin, Benjamin et al. (2006) Germinal center function in the spleen during simian HIV infection in rhesus monkeys. J Immunol 177:1108-19
Yeh, Wendy W; Cale, Evan M; Jaru-Ampornpan, Pimkwan et al. (2006) Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations. J Virol 80:8168-77
LaBonte, Michelle L; McKay, Paul F; Letvin, Norman L (2006) Evidence of NK cell dysfunction in SIV-infected rhesus monkeys: impairment of cytokine secretion and NKG2C/C2 expression. Eur J Immunol 36:2424-33
Barouch, Dan H; Powers, Jennifer; Truitt, Diana M et al. (2005) Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants. Nat Immunol 6:247-52

Showing the most recent 10 out of 138 publications