Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI026123-09
Application #
2063243
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-09-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Barnes, Betsy J; Kellum, Merrill J; Field, Ann E et al. (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22:5721-40
Popik, W; Hesselgesser, J E; Pitha, P M (1998) Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol 72:6406-13
Popik, W; Pitha, P M (1998) Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 Virology 252:210-7
Shirazi, Y; Pitha, P M (1998) Interferon downregulates CXCR4 (fusin) gene expression in peripheral blood mononuclear cells. J Hum Virol 1:69-76
Schafer, S L; Hiscott, J; Pitha, P M (1996) Differential regulation of the HIV-1 LTR by specific NF-kappa B subunits in HSV-1-infected cells. Virology 224:214-23
Kunzi, M S; Pitha, P M (1996) Role of interferon-stimulated gene ISG-15 in the interferon-omega-mediated inhibition of human immunodeficiency virus replication. J Interferon Cytokine Res 16:919-27
Popik, W; Pitha, P M (1996) Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol 16:6532-41
Schafer, S L; Vlach, J; Pitha, P M (1996) Cooperation between herpes simplex virus type 1-encoded ICP0 and Tat to support transcription of human immunodeficiency virus type 1 long terminal repeat in vivo can occur in the absence of the TAR binding site. J Virol 70:6937-46
Megyeri, K; Au, W C; Rosztoczy, I et al. (1995) Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways. Mol Cell Biol 15:2207-18
Kunzi, M S; Farzadegan, H; Margolick, J B et al. (1995) Identification of human immunodeficiency virus primary isolates resistant to interferon-alpha and correlation of prevalence to disease progression. J Infect Dis 171:822-8

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