Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI027690-26
Application #
8503707
Study Section
Special Emphasis Panel (NSS)
Program Officer
Gupta, Kailash C
Project Start
1988-11-01
Project End
2019-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
26
Fiscal Year
2014
Total Cost
$697,500
Indirect Cost
$247,500
Name
Rutgers University
Department
Type
Schools of Medicine
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Miller, Matthew T; Tuske, Steve; Das, Kalyan et al. (2016) Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer. Protein Sci 25:46-55
Neogi, Ujjwal; Häggblom, Amanda; Singh, Kamalendra et al. (2016) Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries. J Antimicrob Chemother 71:367-71
Mullins, Nicholas D; Maguire, Nuala M; Ford, Alan et al. (2016) Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates. Org Biomol Chem 14:2454-65
Das, Kalyan; Balzarini, Jan; Miller, Matthew T et al. (2016) Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. ACS Chem Biol 11:2158-64
Bauman, Joseph D; Harrison, Jerry Joe E K; Arnold, Eddy (2016) Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. IUCrJ 3:51-60
Balzarini, Jan; Das, Kalyan; Bernatchez, Jean A et al. (2015) Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc Natl Acad Sci U S A 112:3475-80
Boyer, Paul L; Das, Kalyan; Arnold, Eddy et al. (2015) Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase. Antimicrob Agents Chemother 59:7184-96
John, Jubi; Kim, Youngju; Bennett, Nicholas et al. (2015) Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates. J Med Chem 58:8110-27
Lee, Won-Gil; Frey, Kathleen M; Gallardo-Macias, Ricardo et al. (2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 25:4824-7
Goswami, Devrishi; Tuske, Steve; Pascal, Bruce D et al. (2015) Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry. Anal Chem 87:4015-22

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