Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI034749-13
Application #
7016310
Study Section
Special Emphasis Panel (NSS)
Program Officer
Sharma, Opendra K
Project Start
1993-12-01
Project End
2009-01-31
Budget Start
2006-02-01
Budget End
2007-01-31
Support Year
13
Fiscal Year
2006
Total Cost
$318,584
Indirect Cost
Name
University of Alabama Birmingham
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Kelly, Maureen C; Kosloff, Barry R; Morrow, Casey D (2007) Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication. Virology 366:330-9
Ni, Na; Morrow, Casey D (2007) Impact of forced selection of tRNAs on HIV-1 replication and genome stability highlight preferences for selection of certain tRNAs. Virus Res 124:29-37
McCulley, Anna; Morrow, Casey D (2007) Nucleotides within the anticodon stem are important for optimal use of tRNA(Lys,3) as the primer for HIV-1 reverse transcription. Virology 364:169-77
Djekic, Uros V; Morrow, Casey D (2007) Analysis of the replication of HIV-1 forced to use tRNAMet(i) supports a link between primer selection, translation and encapsidation. Retrovirology 4:10
Yu, Wanfeng; McCulley, Anna; Morrow, Casey D (2007) Mutations in the TPsiC loop of E. coli tRNALys,3 have varied effects on in trans complementation of HIV-1 replication. Virol J 4:5
Palmer, Matthew T; Kirkman, Richard; Kosloff, Barry R et al. (2007) tRNA isoacceptor preference prior to retrovirus Gag-Pol junction links primer selection and viral translation. J Virol 81:4397-404
Ni, Na; Xu, Wenqin; Morrow, Casey D (2007) Importance of A-loop complementarity with tRNAHis anticodon for continued selection of tRNAHis as the HIV reverse transcription primer. Virol J 4:4
McCulley, Anna; Morrow, Casey D (2006) Complementation of human immunodeficiency virus type 1 replication by intracellular selection of Escherichia coli formula supplied in trans. J Virol 80:9641-50
Xu, Wenqin; Morrow, Casey D (2006) The G490E mutation in reverse transcriptase does not impact tRNA primer selection by HIV-1 with altered PBS and A-loop. Virology 352:380-9
Li, Meng; Eipers, Peter G; Ni, Na et al. (2006) HIV-1 designed to use different tRNAGln isoacceptors prefers to select tRNAThr for replication. Virol J 3:80

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