Studies of the evolution of the viral population following the initiation of anti-retroviral therapy have revealed a dynamic pattern of virus production and cell turnover that has important implications for viral pathogenesis. These new concepts of vial dynamics will provide important information about virus escape from combination antiretroviral therapy and cytotoxic T-lymphocyte killing. In this application, a systematic analysis of plasma virus will provide an indication of the replication events in lymphoid tissue as well as the significance of the plasma virus as a mediator of viral pathogenesis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI035467-06
Application #
2856024
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Plaeger, Susan F
Project Start
1994-01-01
Project End
2002-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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