Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AR021673-20S1
Application #
2520220
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-08-01
Project End
2001-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
20
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Boston Biomedical Research Institute
Department
Type
DUNS #
058893371
City
Watertown
State
MA
Country
United States
Zip Code
02472
Mudalige, Wasana A K A; Tao, Terence C; Lehrer, Sherwin S (2009) Ca2+-dependent photocrosslinking of tropomyosin residue 146 to residues 157-163 in the C-terminal domain of troponin I in reconstituted skeletal muscle thin filaments. J Mol Biol 389:575-83
Luo, Yin; Leszyk, John; Li, Bing et al. (2002) Troponin-I interacts with the Met47 region of skeletal muscle actin. Implications for the mechanism of thin filament regulation by calcium. J Mol Biol 316:429-34
Luo, Yin; Li, Bing; Yang, Guang et al. (2002) Cross-linking between the regulatory regions of troponin-I and troponin-C abolishes the inhibitory function of troponin. Biochemistry 41:12891-8
Li, Z; Gergely, J; Tao, T (2001) Proximity relationships between residue 117 of rabbit skeletal troponin-I and residues in troponin-C and actin. Biophys J 81:321-33
Luo, Y; Leszyk, J; Li, B et al. (2000) Proximity relationships between residue 6 of troponin I and residues in troponin C: further evidence for extended conformation of troponin C in the troponin complex. Biochemistry 39:15306-15
Luo, Y; Wu, J L; Li, B et al. (2000) Photocrosslinking of benzophenone-labeled single cysteine troponin I mutants to other thin filament proteins. J Mol Biol 296:899-910
Moses, M A; Wiederschain, D; Wu, I et al. (1999) Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci U S A 96:2645-50
Tao, T; Gong, B J; Grabarek, Z et al. (1999) Conformational changes induced in troponin I by interaction with troponin T and actin/tropomyosin. Biochim Biophys Acta 1450:423-33
Mabuchi, K; Gong, B J; Langsetmo, K et al. (1999) Isoforms of the small non-catalytic subunit of smooth muscle myosin light chain phosphatase. Biochim Biophys Acta 1434:296-303
Luo, Y; Leszyk, J; Qian, Y et al. (1999) Residues 48 and 82 at the N-terminal hydrophobic pocket of rabbit skeletal muscle troponin-C photo-cross-link to Met121 of troponin-I. Biochemistry 38:6678-88

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