Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA022762-19
Application #
2087091
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1978-02-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chowdhury, A Roy; Long, A; Fuchs, S Y et al. (2017) Mitochondrial stress-induced p53 attenuates HIF-1? activity by physical association and enhanced ubiquitination. Oncogene 36:397-409
Srinivasan, Satish; Guha, Manti; Kashina, Anna et al. (2017) Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection. Biochim Biophys Acta Bioenerg 1858:602-614
Guha, Manti; Srinivasan, Satish; Koenigstein, Alexander et al. (2016) Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene. Ann N Y Acad Sci 1364:52-61
Guha, Manti; Srinivasan, Satish; Guja, Kip et al. (2016) HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Cell Discov 2:16045
Dong, Dawei W; Srinivasan, Satish; Guha, Manti et al. (2015) Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis. Genom Data 6:99-107
Bhattacharya, Sabyasachi; Katlinski, Kanstantsin V; Reichert, Maximilian et al. (2014) Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med 6:384-97
Guha, M; Srinivasan, S; Ruthel, G et al. (2014) Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells. Oncogene 33:5238-50
Guha, Manti; Avadhani, Narayan G (2013) Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion 13:577-91
Tang, Weigang; Chowdhury, Anindya Roy; Guha, Manti et al. (2012) Silencing of IkBýý mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo. Carcinogenesis 33:1762-8
Srinivasan, Satish; Koenigstein, Alexander; Joseph, Joy et al. (2010) Role of mitochondrial reactive oxygen species in osteoclast differentiation. Ann N Y Acad Sci 1192:245-52

Showing the most recent 10 out of 52 publications