Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA028681-17
Application #
2087764
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-07-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Hunter College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065
Boamah, Ernest K; White, David E; Talbott, Kathryn E et al. (2007) Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways. ACS Chem Biol 2:399-407
Paz, Manuel M; Kumar, Gopinatha Suresh; Glover, Mark et al. (2004) Mitomycin dimers: polyfunctional cross-linkers of DNA. J Med Chem 47:3308-19
Abbas, Tarek; Olivier, Magali; Lopez, Jaqueline et al. (2002) Differential activation of p53 by the various adducts of mitomycin C. J Biol Chem 277:40513-9
Palom, Yolanda; Suresh Kumar, Gopinatha; Tang, Li-Qian et al. (2002) Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C. Chem Res Toxicol 15:1398-406
Paz, M M; Das, A; Palom, Y et al. (2001) Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential. J Med Chem 44:2834-42
Paz, M M; Tomasz, M (2001) Reductive activation of mitomycin A by thiols. Org Lett 3:2789-92
Subramaniam, G; Paz, M M; Suresh Kumar, G et al. (2001) Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry 40:10473-84
Paz, M M; Das, T A; Tomasz, M (1999) Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity. Bioorg Med Chem 7:2713-26
Das, A; Tang, K S; Gopalakrishnan, S et al. (1999) Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs. Chem Biol 6:461-71
Ramos, L A; Lipman, R; Tomasz, M et al. (1998) The major mitomycin C-DNA monoadduct is cytotoxic but not mutagenic in Escherichia coli. Chem Res Toxicol 11:64-9

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