Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA033000-24
Application #
6760150
Study Section
Special Emphasis Panel (NSS)
Program Officer
Sussman, Daniel J
Project Start
1982-01-01
Project End
2005-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
24
Fiscal Year
2004
Total Cost
$439,604
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kobayashi, Motohiro; Hoshino, Hitomi; Suzawa, Kenichi et al. (2012) Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases. Semin Immunopathol 34:401-13
Hoshino, Hitomi; Tsuchida, Akiko; Kametani, Kiyokazu et al. (2011) Membrane-associated activation of cholesterol ?-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-?-D-glucopyranoside in Helicobacter pylori critical for its survival. J Histochem Cytochem 59:98-105
Lee, Seung Ho; Yu, Shin-Yi; Nakayama, Jun et al. (2010) Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation. J Biol Chem 285:37683-92
Mitoma, Junya; Fukuda, Minoru (2010) Core O-glycans required for lymphocyte homing gene knockout mice of core 1 beta1,3-N-acetylglucosaminyltransferase and core 2 N-acetylglucosaminyltransferase. Methods Enzymol 479:257-70
Wang, Huan; Tang, Rong; Zhang, Weiyu et al. (2009) Core2 1-6-N-glucosaminyltransferase-I is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 29:180-7
Kobayashi, Motohiro; Lee, Heeseob; Nakayama, Jun et al. (2009) Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection. Glycobiology 19:453-61
Stone, Erica L; Ismail, Mohd Nazri; Lee, Seung Ho et al. (2009) Glycosyltransferase function in core 2-type protein O glycosylation. Mol Cell Biol 29:3770-82
Kobayashi, Motohiro; Fukuda, Minoru; Nakayama, Jun (2009) Role of sulfated O-glycans expressed by high endothelial venule-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseases. Biol Pharm Bull 32:774-9
Kobayashi, Motohiro; Lee, Heeseob; Nakayama, Jun et al. (2009) Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection. Curr Drug Metab 10:29-40
Lee, Seung Ho; Hatakeyama, Shingo; Yu, Shin-Yi et al. (2009) Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. J Biol Chem 284:17157-69

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