Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA033084-24
Application #
7060861
Study Section
Special Emphasis Panel (NSS)
Program Officer
Howcroft, Thomas K
Project Start
1982-08-01
Project End
2007-09-23
Budget Start
2006-05-01
Budget End
2007-09-23
Support Year
24
Fiscal Year
2006
Total Cost
$567,199
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Oda, Shannon K; Daman, Andrew W; Garcia, Nicolas M et al. (2017) A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia. Blood 130:2410-2419
Stromnes, Ingunn M; Hulbert, Ayaka; Pierce, Robert H et al. (2017) T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma. Cancer Immunol Res 5:978-991
Anderson, Kristin G; Stromnes, Ingunn M; Greenberg, Philip D (2017) Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies. Cancer Cell 31:311-325
Chowell, Diego; Krishna, Sri; Becker, Pablo D et al. (2015) TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes. Proc Natl Acad Sci U S A 112:E1754-62
Stromnes, Ingunn M; Schmitt, Thomas M; Hulbert, Ayaka et al. (2015) T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma. Cancer Cell 28:638-652
Kim, Nayoung; Kim, Miju; Yun, Sohyun et al. (2014) MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1. J Allergy Clin Immunol 134:195-203
Stromnes, Ingunn M; DelGiorno, Kathleen E; Greenberg, Philip D et al. (2014) Stromal reengineering to treat pancreas cancer. Carcinogenesis 35:1451-60
Wölfl, Matthias; Greenberg, Philip D (2014) Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells. Nat Protoc 9:950-66
Stromnes, Ingunn M; Brockenbrough, J Scott; Izeradjene, Kamel et al. (2014) Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Gut 63:1769-81
Stromnes, Ingunn M; Greenberg, Philip D; Hingorani, Sunil R (2014) Molecular pathways: myeloid complicity in cancer. Clin Cancer Res 20:5157-70

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