Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37CA038128-15
Application #
2907314
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-07-01
Project End
2005-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
15
Fiscal Year
2000
Total Cost
$364,596
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Berchtold, Craig M; Chen, Kai-Shun; Miyamoto, Shigeki et al. (2005) Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. Cancer Res 65:8558-66
Clark, S S; Perman, S M; Sahin, M B et al. (2002) Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. Leukemia 16:213-22
Shi, Wenge; Gould, Michael N (2002) Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. Carcinogenesis 23:131-42
Ripple, G H; Gould, M N; Arzoomanian, R Z et al. (2000) Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clin Cancer Res 6:390-6
Ariazi, E A; Satomi, Y; Ellis, M J et al. (1999) Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res 59:1917-28
Satomi, Y; Miyamoto, S; Gould, M N (1999) Induction of AP-1 activity by perillyl alcohol in breast cancer cells. Carcinogenesis 20:1957-61
Ren, Z; Gould, M N (1998) Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells. Carcinogenesis 19:827-32
Ripple, G H; Gould, M N; Stewart, J A et al. (1998) Phase I clinical trial of perillyl alcohol administered daily. Clin Cancer Res 4:1159-64
Ren, Z; Elson, C E; Gould, M N (1997) Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells. Biochem Pharmacol 54:113-20
Ariazi, E A; Gould, M N (1996) Consecutive cycles of precise, unidirectional 14-bp deletions using a BseRI/BsgI trimming plasmid. Biotechniques 20:446-8, 450-1

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