The Multiethnic Cohort (MEC) Study was designed to prospectively investigate the relationship of diet and other lifestyle factors to cancer risk in five ethnic groups (African Americans, Japanese Americans, Latinos, Native Hawaiians and Caucasians),and to explore interactions between these risk factors and genetic susceptibility to cancer. Since establishment of the cohort in 1993-96, more than 10 years of follow-up have accrued on the 215,000 participants, bringing the project to a point where its full potential can now be realized. In the current cycle of support, we are re-administering the baseline questionnaire to obtain updated (10-year) dietary and other information on the subjects (e.g., smoking, physical activity, hormonal usage, medications, intercurrent illnesses). We have been analyzing data from the baseline questionnaire, both dietary and non-dietary, as well as data on genetic susceptibility and gene-environment interactions. Altogether, we have published 50 papers from the cohort since early 2003. We have been among the most active participants in NCI's Breast and Prostate Cancer Cohort Consortium, and have shared our data with other members of the consortium, as well as with investigators at outside institutions. For the next 5-year period, we have several dietary scientific aims, including further research into the basis for ethnic differences we observed in diet and cancer relationships, investigation of hypotheses related to dietary constituents recently added to our food composition table (e.g., trans fatty acids, heme iron, glycemic load, heterocyclic amines), study of some less common sites (e.g., non-Hodgkin's lymphoma, ovary and kidney), more in-depth subgroup analyses (e.g., by histology and stage), and investigations of the relationship of diet to cancer survival. We also have several non-dietary scientific aims, particularly related to investigating as- yet unexplainable ethnic differences in breast and lung cancer risk. The important work necessary to maintain the cohort and its several databases will continue, including administration of another short follow- up questionnaire and regular enhancements to the unique food composition table. Finally, we will continue to train graduate students and postdoctoral fellows. We expect this research not only to expand knowledge of the role of environmental risk factors and genes in cancer risk, but also to further an understanding of the basis for ethnic/racial disparities in cancer occurrence and survival.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA054281-20
Application #
8234215
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mahabir, Somdat
Project Start
1983-01-01
Project End
2013-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
20
Fiscal Year
2012
Total Cost
$2,276,925
Indirect Cost
$383,023
Name
University of Hawaii
Department
None
Type
Organized Research Units
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Leo, Q J N; Ollberding, N J; Wilkens, L R et al. (2016) Nutritional factors and non-Hodgkin lymphoma survival in an ethnically diverse population: the Multiethnic Cohort. Eur J Clin Nutr 70:41-6
Petridis, Christos; Brook, Mark N; Shah, Vandna et al. (2016) Genetic predisposition to ductal carcinoma in situ of the breast. Breast Cancer Res 18:22
Park, Sungshim L; Tiirikainen, Maarit I; Patel, Yesha M et al. (2016) Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity. Carcinogenesis 37:269-79
Maskarinec, G; Morimoto, Y; Jacobs, S et al. (2016) Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. Eur J Clin Nutr 70:1022-7
Vigen, Cheryl; Kwan, Marilyn L; John, Esther M et al. (2016) Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC). Cancer Causes Control 27:391-401
(2016) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol 141:386-401
Garcia-Albeniz, Xabier; Rudolph, Anja; Hutter, Carolyn et al. (2016) CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk. Br J Cancer 114:221-9
Travis, Ruth C; Appleby, Paul N; Martin, Richard M et al. (2016) A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk. Cancer Res 76:2288-300
Sposto, Richard; Keegan, Theresa H M; Vigen, Cheryl et al. (2016) The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiol Biomarkers Prev 25:1064-72
Zanetti, Krista A; Wang, Zhaoming; Aldrich, Melinda et al. (2016) Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer 98:33-42

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