This is an application for a Research Supplement to Promote Diversity in Health-Related Research (PA-18-586). The Parent R37 Project associated with this application is entitled ?Post- translational Regulation of Opioid and Cannabinoid Receptors? supported by NIDA (R37DA08863-23). Seshat Mack is the diversity candidate. She is a US citizen of African- American descent and is currently an MD/PhD graduate student at Icahn School of Medicine at Mount Sinai, New York. The main goal of this study is the characterization of a newly deorphanized striatal neuropeptide receptor involved in modulating rewarding behaviors.
These studies are likely to open new avenues of research relating to neuroendocrine regulation of reward- related disorders. In addition to providing essential information about signaling by this novel neuropeptide- receptor system, these studies describe compounds with great research and/or therapeutic potential.
|Heimann, Andrea S; Gupta, Achla; Gomes, Ivone et al. (2018) Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states. PLoS One 13:e0193322|
|Fricker, Lloyd D; Devi, Lakshmi A (2018) Orphan neuropeptides and receptors: Novel therapeutic targets. Pharmacol Ther 185:26-33|
|Lueptow, Lindsay M; Devi, Lakshmi A; Fakira, Amanda K (2018) Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Neuropsychiatric Disorders. Prog Mol Biol Transl Sci 159:1-25|
|Margolis, Elyssa B; Fujita, Wakako; Devi, Lakshmi A et al. (2017) Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor. Neuropharmacology 123:420-432|
|Reckziegel, Patrícia; Festuccia, William T; Britto, Luiz R G et al. (2017) A novel peptide that improves metabolic parameters without adverse central nervous system effects. Sci Rep 7:14781|
|Heimann, Andrea S; Gupta, Achla; Gomes, Ivone et al. (2017) Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states. PLoS One 12:e0187306|
|Bobeck, Erin N; Gomes, Ivone; Pena, Darlene et al. (2017) The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology 42:2527-2536|
|Gomes, Ivone; Sierra, Salvador; Devi, Lakshmi A (2016) Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay. Curr Protoc Pharmacol 75:2.16.1-2.16.31|
|Gomes, Ivone; Bobeck, Erin N; Margolis, Elyssa B et al. (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal 9:ra43|
|Wardman, Jonathan H; Gomes, Ivone; Bobeck, Erin N et al. (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal 9:ra55|
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