Basement membranes (BMs) are cell-associated extracellular matrices formed initially as laminin Dolymer scaffoldings. They act as solid-phase agonists for adherent tissue cells, profoundly affecting their differentiation, organization and maintenance. Defects of BM components and structure are a cause of
Aim II. Post-anchorage laminin and basement membrane functions.
Aim 1 11. Architectural and other laminin short-arm functions. To address these, we propose to integrate the approaches of using recombinant laminins with specific function- altering mutations to analyze assembly and cell differentiation in normal and genetically-modified EBs, renal tubular epithelial and other BM-assembling cells backed by mouse genetics to validate our hypotheses.
|Pozzi, Ambra; Yurchenco, Peter D; Iozzo, Renato V (2017) The nature and biology of basement membranes. Matrix Biol 57-58:1-11|
|van Wijk, Xander M; Döhrmann, Simon; Hallström, Björn M et al. (2017) Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin ?2 as a Host Factor for Bacterial Invasion. MBio 8:|
|Colombelli, Cristina; Palmisano, Marilena; Eshed-Eisenbach, Yael et al. (2015) Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol 208:313-29|
|Hohenester, Erhard; Yurchenco, Peter D (2013) Laminins in basement membrane assembly. Cell Adh Migr 7:56-63|
|McKee, Karen K; Yang, Dong-Hua; Patel, Rajesh et al. (2012) Schwann cell myelination requires integration of laminin activities. J Cell Sci 125:4609-19|
|Yurchenco, Peter D (2011) Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol 3:|
|Yang, Dong-Hua; McKee, Karen K; Chen, Zu-Lin et al. (2011) Renal collecting system growth and function depend upon embryonic ?1 laminin expression. Development 138:4535-44|
|He, Xiaowen; Liu, Jie; Qi, Yanmei et al. (2010) Rac1 is essential for basement membrane-dependent epiblast survival. Mol Cell Biol 30:3569-81|
|McKee, Karen K; Capizzi, Stephanie; Yurchenco, Peter D (2009) Scaffold-forming and Adhesive Contributions of Synthetic Laminin-binding Proteins to Basement Membrane Assembly. J Biol Chem 284:8984-94|
|Yurchenco, Peter D; Patton, Bruce L (2009) Developmental and pathogenic mechanisms of basement membrane assembly. Curr Pharm Des 15:1277-94|
Showing the most recent 10 out of 35 publications