Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK039585-08
Application #
2140971
Study Section
Special Emphasis Panel (NSS)
Project Start
1988-04-01
Project End
1996-11-30
Budget Start
1995-04-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Anderson, K P; Crable, S C; Lingrel, J B (1998) Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Kruppel-like factor (EKLF) gene. J Biol Chem 273:14347-54
Anderson, K P; Kern, C B; Crable, S C et al. (1996) Analysis of developmental switching in transgenic mice with 5' and 3' deletions in the human beta globin gene. Transgenic Res 5:245-55
Anderson, K P; Kern, C B; Crable, S C et al. (1995) Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol 15:5957-65
Lloyd, J A; Case, S S; Ponce, E et al. (1994) Positive transcriptional regulation of the human gamma-globin gene. Gamma PE is a novel nuclear factor with multiple binding sites near the gene. J Biol Chem 269:19385-93
Krakowsky, J M; Boissy, R E; Neumann, J C et al. (1993) A DNA insertional mutation results in microphthalmia in transgenic mice. Transgenic Res 2:14-20
Anderson, K P; Lloyd, J A; Ponce, E et al. (1993) Regulated expression of the human beta globin gene in transgenic mice requires an upstream globin or nonglobin promoter. Mol Biol Cell 4:1077-85
Boissy, R E; Boissy, Y L; Krakowsky, J M et al. (1993) Ocular pathology in mice with a transgenic insertion at the microphthalmia locus. J Submicrosc Cytol Pathol 25:319-32
Lloyd, J A; Krakowsky, J M; Crable, S C et al. (1992) Human gamma- to beta-globin gene switching using a mini construct in transgenic mice. Mol Cell Biol 12:1561-7
Ponce, E; Lloyd, J A; Pierani, A et al. (1991) Transcription factor OTF-1 interacts with two distinct DNA elements in the A gamma-globin gene promoter. Biochemistry 30:2961-7
Krakowsky, J M; Panke, E S; Lee, R F et al. (1989) Analysis of possible repressor elements in the 5'-flanking region of the human beta-globin gene. DNA 8:715-21

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