The function of the Animal Core is to produce and maintain all of the animals required for the scientific project for this and several other program project grants. The specific services of the Animal Core personnel include 1) Providing the highest quality animal and veterinary care, 2) Production of transgenic and knockout mice, 3) Performing experimental inoculations, neurologic scoring of animals, data collection, and tissue collection, 4) Performing dosing and toxicology studies for novel drugs, 5) Providing transportation of animals and tissues between the laboratory and the animal facility, 6) Production of antibodies in mice and rabbits for experimental use, 6) Providing all animal care and veterinary care, 7) Production of large volumes of scrapie infected hamster and mouse brains for purification, 8) Providing cryopreservation of the various mouse lines. The Animal Core operates in two purpose-built facilities in the Hunters Point area of San Francisco, approximately 7 miles from the main UCSF campus. Its activities are directed by Dr. Prusiner and Dr. Pierre Lessard, a laboratory animal veterinarian. Building 830B is a new nine room transgenic mouse breeding facility that houses our large breeding colony. Building 830 houses all the experimental animals in 21 rooms, under BSL-2 and 3 biocontainment. It houses on average 10,000 mice, 400 hamsters, and 8 rabbits. The facility is inspected annually by USDA, and bi-annually by UCSF/IACUC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK043225-21
Application #
8010887
Study Section
Special Emphasis Panel (NSS)
Program Officer
Serrano, Jose
Project Start
1991-01-01
Project End
2013-12-31
Budget Start
2011-01-01
Budget End
2011-12-31
Support Year
21
Fiscal Year
2011
Total Cost
$353,664
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhang, Weizhen; Chang, Lin; Zhang, Chao et al. (2015) Central and peripheral irisin differentially regulate blood pressure. Cardiovasc Drugs Ther 29:121-7
Zhang, Weizhen; Chang, Lin; Zhang, Chao et al. (2015) Irisin: A myokine with locomotor activity. Neurosci Lett 595:7-11
Zhang, Weizhen; Zhang, Chao; Fritze, Danielle et al. (2013) Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1. Exp Physiol 98:1696-704
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Li, Ziru; Xu, Geyang; Li, Yin et al. (2012) mTOR-dependent modulation of gastric nesfatin-1/NUCB2. Cell Physiol Biochem 29:493-500
Li, Ji-Yao; Chai, Biaoxin; Zhang, Weizhen et al. (2011) Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neurosci 12:95
Wu, X; Zhang, W; Li, J-Y et al. (2011) Induction of apoptosis by thrombin in the cultured neurons of dorsal motor nucleus of the vagus. Neurogastroenterol Motil 23:279-85, e123-4
An, Wenjiao; Li, Yin; Xu, Geyang et al. (2010) Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 26:707-16
Chai, Biaoxin; Li, Ji-Yao; Zhang, Weizhen et al. (2010) Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling. Peptides 31:1888-93

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