III. Abstract of Research Plan for Extension Period (5 years) 1. To examine the role of co-repressors, e.g., HDAC, Sin3A, in menin-mediated inhibition of gastrin 2. To examine the role of somatostatin in regulation of co-repressors 3. To determine the role of somatostatin and menin in the regulation of p27 and cell proliferation. Role of MLL. Are duodenal gastrinomas of myeloid origin?
Relevance to publish health include furthering our understanding of peptic ulcer disease, neuroendocrine transformation and the molecular basis underlying the effects of SOM analogs used to treat neuroendocrine disorders.
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|Mensah-Osman, Edith J; Veniaminova, Natalia A; Merchant, Juanita L (2011) Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol 301:G783-90|
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|Mensah-Osman, Edith; Zavros, Yana; Merchant, Juanita L (2008) Somatostatin stimulates menin gene expression by inhibiting protein kinase A. Am J Physiol Gastrointest Liver Physiol 295:G843-54|
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