Program Director/Principal Investigator (Last, First, Middle): M c M a h o n , A n d r e w PROJECT SUMMA,RY (See instotctions): The mammalian kidney has a rich history of embryological study, its physiological actions are well understood and kidney disease is one of the leading health care issues. For these and other reasons (for example the (dynamic cellular events intrinsic to the kidney program), we have chosen to focus on this system. As we wish to relate our findings as directly as possible to the clinic, the mouse is our rnodel. Combining genetic, genomic and biochemical strategies, the proposed research will define and mechanistically dissect key regulatory processes in the developing mammalian kidney.

Public Health Relevance

Our goal is do determine how nephron generating stem cells are regulated to enable new approaches to treat kidney disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Method to Extend Research in Time (MERIT) Award (R37)
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Special Emphasis Panel (NSS)
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Hoshizaki, Deborah K
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University of Southern California
Los Angeles
United States
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Kumar, Sanjeev; Liu, Jing; McMahon, Andrew P (2014) Defining the acute kidney injury and repair transcriptome. Semin Nephrol 34:404-17
O'Brien, Lori L; McMahon, Andrew P (2014) Induction and patterning of the metanephric nephron. Semin Cell Dev Biol 36:31-8
Kobayashi, Akio; Mugford, Joshua W; Krautzberger, A Michaela et al. (2014) Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports 3:650-62
Mae, Shin-Ichi; Shono, Akemi; Shiota, Fumihiko et al. (2013) Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun 4:1367
DiRocco, Derek P; Kobayashi, Akio; Taketo, Makoto M et al. (2013) Wnt4/*-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 24:1399-412
Nagalakshmi, Vidya K; Ren, Qun; Pugh, Margaret M et al. (2011) Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int 79:317-30
Boyle, Scott C; Kim, Mijin; Valerius, M Todd et al. (2011) Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development 138:4245-54
Lin, Shuei-Liong; Li, Bing; Rao, Sujata et al. (2010) Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A 107:4194-9
Humphreys, Benjamin D; Lin, Shuei-Liong; Kobayashi, Akio et al. (2010) Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176:85-97
Yu, Jing; Carroll, Thomas J; Rajagopal, Jay et al. (2009) A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136:161-71

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