Abstract

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  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK058282-19
Application #
9553777
Study Section
Special Emphasis Panel (NSS)
Program Officer
Silva, Corinne M
Project Start
2015-09-01
Project End
2020-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
19
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Accili, Domenico (2018) Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture. Diabetes 67:1701-1709
Haeusler, Rebecca A; McGraw, Timothy E; Accili, Domenico (2018) Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol 19:31-44
Langlet, Fanny; Haeusler, Rebecca A; Lindén, Daniel et al. (2017) Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell 171:824-835.e18
O'Neill, Brian T; Lee, Kevin Y; Klaus, Katherine et al. (2016) Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest 126:3433-46
Vazirani, Reema P; Verma, Akanksha; Sadacca, L Amanda et al. (2016) Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes 65:1577-89
Pajvani, Utpal B; Accili, Domenico (2015) The new biology of diabetes. Diabetologia 58:2459-68
Ren, Hongxia; Lu, Taylor Y; McGraw, Timothy E et al. (2015) Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons. Diabetes 64:405-17
Ren, Hongxia; Cook, Joshua R; Kon, Ning et al. (2015) Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin. Diabetes 64:3670-9
Bouchi, Ryotaro; Foo, Kylie S; Hua, Haiqing et al. (2014) FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures. Nat Commun 5:4242
Ren, Hongxia; Yan, Shijun; Zhang, Baifang et al. (2014) Glut4 expression defines an insulin-sensitive hypothalamic neuronal population. Mol Metab 3:452-9

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