We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis.
Our specific aims i nclude studying basic ozone chemistry and the chemistry of the ozone-derived oxidants, carbonyl oxides and dioxiranes. PAH's absorbed on model particulates will be exposed to a gas stream containing: 1) ozone and 2) an ozone-alkene reaction mixture. Differences in product distributions in these two types of reactions will indicate reactions between the PAH's and ozone-derived oxidants. The presence of arene oxides in the ozone-alkene experiments could be related to the production of mutagens/carcinogens in polluted atmospheres. The nature of the responsible oxidant (carbonyl oxide or dioxirane) will be determined. Ozonolysis of solutions of tetra-substituted alkenes at varying concentration will be studied for evidence of dioxirane formation. Improved methods for the synthesis of dioxiranes will be sought. The reactions of dioxiranes with saturated hydrocarbons will be studied under a variety of reaction conditions. Solvent effects on the rate of epoxidation by dioxiranes will be measured.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37ES001984-16
Application #
2153094
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1979-03-01
Project End
1995-02-28
Budget Start
1994-03-01
Budget End
1995-02-28
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Missouri-St. Louis
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63121
Murray, R W; Singh, M (2000) Enantioselective formation of arene oxides by direct oxidation of the arene. Enantiomer 5:245-54
Murray, R W; Singh, M; Rath, N P (1999) Arene dioxides of substituted pyrenes: synthesis and X-ray structural studies. Carcinogenesis 20:147-52
Murray, R W; Singh, M (1998) Oxidative transformations of 1-nitropyrene under simulated environmental conditions. Chem Res Toxicol 11:449-53
Rath, N P; Gu, H; Murray, R W (1997) 1-Acetyl-3-hydroxyadamantane and 1-carboxy-3-hydroxyadamantane. Acta Crystallogr C 53 ( Pt 7):944-6