Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37EY004096-15
Application #
2158995
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Fishkin, Nathan; Yefidoff, Revital; Gollipalli, Deviprasad R et al. (2005) On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle. Bioorg Med Chem 13:5189-94
Xue, Linlong; Rando, Robert R (2004) Roles of cysteine 161 and tyrosine 154 in the lecithin-retinol acyltransferase mechanism. Biochemistry 43:6120-6
Xue, Linlong; Gollapalli, Deviprasad R; Maiti, Pranab et al. (2004) A palmitoylation switch mechanism in the regulation of the visual cycle. Cell 117:761-71
Gollapalli, Deviprasad R; Rando, Robert R (2004) The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Proc Natl Acad Sci U S A 101:10030-5
Gollapalli, Deviprasad R; Rando, Robert R (2003) Molecular logic of 11-cis-retinoid biosynthesis in a cone-dominated species. Biochemistry 42:14921-9
Krosky, Paula M; Baek, Moon-Chang; Jahng, Wan Jin et al. (2003) The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. J Virol 77:7720-7
Jahng, Wan Jin; Xue, Linlong; Rando, Robert R (2003) Lecithin retinol acyltransferase is a founder member of a novel family of enzymes. Biochemistry 42:12805-12
Gollapalli, Deviprasad R; Maiti, Pranab; Rando, Robert R (2003) RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters. Biochemistry 42:11824-30
Gollapalli, Deviprasad R; Rando, Robert R (2003) All-trans-retinyl esters are the substrates for isomerization in the vertebrate visual cycle. Biochemistry 42:5809-18
Bok, Dean; Ruiz, Alberto; Yaron, Orna et al. (2003) Purification and characterization of a transmembrane domain-deleted form of lecithin retinol acyltransferase. Biochemistry 42:6090-8

Showing the most recent 10 out of 53 publications