Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM006920-36
Application #
2166095
Study Section
Special Emphasis Panel (NSS)
Project Start
1975-09-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
36
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Lipscomb, William N; Kantrowitz, Evan R (2012) Structure and mechanisms of Escherichia coli aspartate transcarbamoylase. Acc Chem Res 45:444-53
Lipscomb, W N (1994) Aspartate transcarbamylase from Escherichia coli: activity and regulation. Adv Enzymol Relat Areas Mol Biol 68:67-151
Xue, Y; Huang, S; Liang, J Y et al. (1994) Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors. Proc Natl Acad Sci U S A 91:12482-6
Chook, Y M; Gray, J V; Ke, H et al. (1994) The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction. J Mol Biol 240:476-500
Zhang, Y; Liang, J Y; Huang, S et al. (1994) Toward a mechanism for the allosteric transition of pig kidney fructose-1,6-bisphosphatase. J Mol Biol 244:609-24
Reinisch, K M; Chen, L; Verdine, G L et al. (1994) Crystallization and preliminary crystallographic analysis of a DNA (cytosine-5)-methyltransferase from Haemophilus aegyptius bound covalently to DNA. J Mol Biol 238:626-9
Kim, H; Lipscomb, W N (1994) Structure and mechanism of bovine lens leucine aminopeptidase. Adv Enzymol Relat Areas Mol Biol 68:153-213
Xue, Y; Lipscomb, W N (1994) The crystallization and preliminary X-ray analysis of allosteric chorismate mutase. J Mol Biol 241:273-4
Gidh-Jain, M; Zhang, Y; van Poelje, P D et al. (1994) The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure. J Biol Chem 269:27732-8
Xue, Y; Lipscomb, W N; Graf, R et al. (1994) The crystal structure of allosteric chorismate mutase at 2.2-A resolution. Proc Natl Acad Sci U S A 91:10814-8

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