Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM018568-24
Application #
2173358
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
24
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
DeLoughery, Aaron; Lalanne, Jean-BenoƮt; Losick, Richard et al. (2018) Maturation of polycistronic mRNAs by the endoribonuclease RNase Y and its associated Y-complex in Bacillus subtilis. Proc Natl Acad Sci U S A 115:E5585-E5594
Russell, Jonathan R; Cabeen, Matthew T; Wiggins, Paul A et al. (2017) Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. EMBO J 36:2856-2869
DeFrancesco, Alicia S; Masloboeva, Nadezda; Syed, Adnan K et al. (2017) Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus. Proc Natl Acad Sci U S A 114:E5969-E5978
Flanagan, Kelly A; Comber, Joseph D; Mearls, Elizabeth et al. (2016) A Membrane-Embedded Amino Acid Couples the SpoIIQ Channel Protein to Anti-Sigma Factor Transcriptional Repression during Bacillus subtilis Sporulation. J Bacteriol 198:1451-63
Cabeen, Matthew T; Leiman, Sara A; Losick, Richard (2016) Colony-morphology screening uncovers a role for the Pseudomonas aeruginosa nitrogen-related phosphotransferase system in biofilm formation. Mol Microbiol 99:557-70
DeLoughery, Aaron; Dengler, Vanina; Chai, Yunrong et al. (2016) Biofilm formation by Bacillus subtilis requires an endoribonuclease-containing multisubunit complex that controls mRNA levels for the matrix gene repressor SinR. Mol Microbiol 99:425-37
Leiman, Sara A; Richardson, Charles; Foulston, Lucy et al. (2015) Identification and characterization of mutations conferring resistance to D-amino acids in Bacillus subtilis. J Bacteriol 197:1632-9
Tucker, Ashley T; Bobay, Benjamin G; Banse, Allison V et al. (2014) A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. J Mol Biol 426:1911-24
Leiman, Sara A; Arboleda, Laura C; Spina, Joseph S et al. (2014) SinR is a mutational target for fine-tuning biofilm formation in laboratory-evolved strains of Bacillus subtilis. BMC Microbiol 14:301
Elsholz, Alexander K W; Wacker, Sarah A; Losick, Richard (2014) Self-regulation of exopolysaccharide production in Bacillus subtilis by a tyrosine kinase. Genes Dev 28:1710-20

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