Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM034236-18
Application #
6399333
Study Section
Special Emphasis Panel (NSS)
Program Officer
Long, Rochelle M
Project Start
1988-04-01
Project End
2007-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
18
Fiscal Year
2002
Total Cost
$417,280
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Pero, Ralph S; Borchers, Michael T; Spicher, Karsten et al. (2007) Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation. Proc Natl Acad Sci U S A 104:4371-6
Shin, Kum-Joo; Wall, Estelle A; Zavzavadjian, Joelle R et al. (2006) A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A 103:13759-64
Hwang, Jong-Ik; Choi, Sangdun; Fraser, Iain D C et al. (2005) Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins. Proc Natl Acad Sci U S A 102:9493-8
Hwang, Jong-Ik; Fraser, Iain D C; Choi, Sangdun et al. (2004) Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA. Proc Natl Acad Sci U S A 101:488-93
Slice, Lee W; Han, Sang-Kyou; Simon, Melvin I (2003) Galphaq signaling is required for Rho-dependent transcriptional activation of the cyclooxygenase-2 promoter in fibroblasts. J Cell Physiol 194:127-38
Bastiani, Carol A; Gharib, Shahla; Simon, Melvin I et al. (2003) Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. Genetics 165:1805-22
Han, Sang-Kyou; Dong, Xinzhong; Hwang, Jong-Ik et al. (2002) Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc Natl Acad Sci U S A 99:14740-5
Dong, X; Han, S; Zylka, M J et al. (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106:619-32
Offermanns, S; Negulescu, P; Hu, Y H et al. (2001) Conditionally expressed G alpha 15 couples to endogenous receptors in GH3 cells. Naunyn Schmiedebergs Arch Pharmacol 364:140-8
Kabarowski, J H; Feramisco, J D; Le, L Q et al. (2000) Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. Proc Natl Acad Sci U S A 97:12109-14

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