Our lab has been focused on how cells sense and respond to DNA damage. We have been very active n elucidating the structures sensed by the DNA damage response sensors. Through work in both yeast and mammals we have established an outline of the signal transduction pathway that is activated in response to DNA damage. This pathway consists of a protein kinase cascade. We have been very interested in understanding how the DNA damage response controls various aspects of cell cycle regulation and have therefore studied the cell cycle as well. In order to understand how the DNA damage response accomplishes its goals, it is imperative we identify the substrates of the kinases activated in response to DNA damage and elucidate the function of these substrates.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM044664-24
Application #
8319419
Study Section
Special Emphasis Panel (NSS)
Program Officer
Janes, Daniel E
Project Start
1990-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$343,035
Indirect Cost
$147,015
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Zhu, Jian; Gaiha, Gaurav D; John, Sinu P et al. (2012) Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep 2:807-16
Elia, Andrew E H; Elledge, Stephen J (2012) BRCA1 as tumor suppressor: lord without its RING? Breast Cancer Res 14:306
Adamson, Britt; Smogorzewska, Agata; Sigoillot, Frederic D et al. (2012) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol 14:318-28

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