Abstract

The Sasisekharan laboratory focuses on developing tools to study glycan-protein interactions. The laboratory has focused on using these tools to not only instigate the fundamentals of glycans in terms of how they impact biological processes, but they have also harnessed the mechanisms to address important public health crises including the contamination of heparin disaster. The tools developed have implications beyond glycobiology.

Public Health Relevance

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM057073-19
Application #
9099856
Study Section
Special Emphasis Panel (NSS)
Program Officer
Marino, Pamela
Project Start
2015-08-01
Project End
2020-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
19
Fiscal Year
2016
Total Cost
$390,000
Indirect Cost
$140,000

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02142

  Publications

Tharakaraman, Kannan; Watanabe, Satoru; Chan, Kuan Rong et al. (2018) Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope. Cell Host Microbe 23:618-627.e6
Quinlan, Devin S; Raman, Rahul; Tharakaraman, Kannan et al. (2017) An inter-residue network model to identify mutational-constrained regions on the Ebola coat glycoprotein. Sci Rep 7:45886
Raguram, Aditya; Sasisekharan, V; Sasisekharan, Ram (2017) AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures. Trends Microbiol 25:438-446
Ramakrishnan, Boopathy; Viswanathan, Karthik; Tharakaraman, Kannan et al. (2016) A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza. Trends Microbiol 24:933-943
Macchi, Eleonora; Rudd, Timothy R; Raman, Rahul et al. (2016) Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. Biochemistry 55:6605-6616
Raman, Rahul; Tharakaraman, Kannan; Sasisekharan, V et al. (2016) Glycan-protein interactions in viral pathogenesis. Curr Opin Struct Biol 40:153-162
Shriver, Zachary; Sasisekharan, Ram (2015) Capillary electrophoretic analysis of isolated sulfated polysaccharides to characterize pharmaceutical products. Methods Mol Biol 1229:161-71
Zhu, Xueyong; Viswanathan, Karthik; Raman, Rahul et al. (2015) Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep 13:1683-91
Robinson, Luke N; Tharakaraman, Kannan; Rowley, Kirk J et al. (2015) Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Cell 162:493-504
Tharakaraman, Kannan; Subramanian, Vidya; Viswanathan, Karthik et al. (2015) A broadly neutralizing human monoclonal antibody is effective against H7N9. Proc Natl Acad Sci U S A 112:10890-5

Showing the most recent 10 out of 56 publications