Program Director/Principal Investigator (Last, First, Middle): Sanchez AlvaradO, Alejandro PROJECT SUIVIMARY (See instructions): The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. This project takes advantage of methodological advances and findings obtained during the last funding period to: 1) define a high temporal resolution, genome-wide, expression profile of regeneration;2) interrogate the functions of known embryonic signaling pathways in the adult contexts of tissue regeneration and homeostasis, and to carry out a formal comparison of how the mechanisms of regeneration compare to embryogenesis;3) uncover genes involved in the regeneration of adult organs after amputation;and 4) Initiate comparative studies of regeneration to test the universality of our findings. All three lines of investigation synergize with each other and their integration should provide us with a high-resolution set of molecular processes regulating regeneration and regenerative capacities. Thus far, this approach has led us to uncover novel animal cell biology and functions in adult contexts of known genes, and to define functions for the many conserved animal genes for which functions are still unknown. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health.
The overarching goal of this project is to define a mechanistic basis for the process of animal regeneration. Given the high degree of evolutionary conservation that exits between planarians and vertebrates, the characterization of gene functions in planarians will advance efforts to study human stem-cell function, regeneration and wound healing, effectively advancing these frontiers of human health.
|Adler, Carolyn E; Sánchez Alvarado, Alejandro (2017) PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration. Dev Biol 427:165-175|
|Davies, Erin L; Lei, Kai; Seidel, Christopher W et al. (2017) Embryonic origin of adult stem cells required for tissue homeostasis and regeneration. Elife 6:|
|Ross, Eric; Blair, David; Guerrero-Hernández, Carlos et al. (2016) Comparative and Transcriptome Analyses Uncover Key Aspects of Coding- and Long Noncoding RNAs in Flatworm Mitochondrial Genomes. G3 (Bethesda) 6:1191-200|
|Lei, Kai; Thi-Kim Vu, Hanh; Mohan, Ryan D et al. (2016) Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians. Dev Cell 38:413-29|
|Arnold, Christopher P; Merryman, M Shane; Harris-Arnold, Aleishia et al. (2016) Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38. Elife 5:|
|Duncan, Elizabeth M; Chitsazan, Alex D; Seidel, Chris W et al. (2015) Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo. Cell Rep 13:2741-55|
|Tu, Kimberly C; Cheng, Li-Chun; T K Vu, Hanh et al. (2015) Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. Elife 4:e10501|
|Adler, Carolyn E; Sánchez Alvarado, Alejandro (2015) Types or States? Cellular Dynamics and Regenerative Potential. Trends Cell Biol 25:687-96|
|Robb, Sofia M C; Gotting, Kirsten; Ross, Eric et al. (2015) SmedGD 2.0: The Schmidtea mediterranea genome database. Genesis 53:535-46|
|Thi-Kim Vu, Hanh; Rink, Jochen C; McKinney, Sean A et al. (2015) Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ. Elife 4:|
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