Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM074593-35
Application #
9539365
Study Section
Special Emphasis Panel (NSS)
Program Officer
Bender, Michael T
Project Start
1984-04-01
Project End
2023-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
35
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Elbarbary, Reyad A; Miyoshi, Keita; Myers, Jason R et al. (2017) Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science 356:859-862
Elbarbary, Reyad A; Maquat, Lynne E (2017) Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism. Nat Struct Mol Biol 24:496-498
Elbarbary, Reyad A; Miyoshi, Keita; Hedaya, Omar et al. (2017) UPF1 helicase promotes TSN-mediated miRNA decay. Genes Dev 31:1483-1493
Gleghorn, Michael L; Zhao, Jianbo; Turner, Douglas H et al. (2016) Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation. Nucleic Acids Res 44:8417-24
Elbarbary, Reyad A; Lucas, Bronwyn A; Maquat, Lynne E (2016) Retrotransposons as regulators of gene expression. Science 351:aac7247
Elbarbary, Reyad A; Maquat, Lynne E (2016) Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock. Genes Dev 30:487-8
Maquat, Lynne E (2016) Eukaryotic antisense ahead of its time. Nat Rev Mol Cell Biol 17:204
Elbarbary, Reyad A; Maquat, Lynne E (2015) CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention. Genes Dev 29:687-9
Maquat, Lynne E (2015) The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences. RNA 21:488-9
Gong, Chenguang; Maquat, Lynne E (2015) Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods Mol Biol 1206:81-6

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