Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL034636-10
Application #
3486077
Study Section
Pathology A Study Section (PTHA)
Project Start
1985-07-01
Project End
1998-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Zhou, Yi; Chen, Huimei; Liu, Li et al. (2017) Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol 198:1846-1854
Zhou, Yi; Chen, Huimei; Liu, Li et al. (2017) CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol 198:2568-2577
Wang, Jing; Sun, Chongxiu; Gerdes, Norbert et al. (2015) Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med 21:820-6
Wang, Jing; Lindholt, Jes S; Sukhova, Galina K et al. (2014) IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med 6:952-69
Tang, Eva H C; Libby, Peter; Vanhoutte, Paul M et al. (2012) Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol 59:116-23
Cheng, Xiang; Wang, Jing; Xia, Ni et al. (2012) A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med 4:1112-25
Tang, Eva H C; Shvartz, Eugenia; Shimizu, Koichi et al. (2011) Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 31:261-9
Shimizu, Koichi; Libby, Peter; Rocha, Viviane Z et al. (2011) Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation 124:2920-32
Wang, Jing; Cheng, Xiang; Xiang, Mei-Xiang et al. (2011) IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest 121:3564-77
Wolf, Dennis; Hohmann, Jan-David; Wiedemann, Ansgar et al. (2011) Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res 109:1269-79

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