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Public Health Relevance

We are trying to understand how anti-inflammatory steroids like cortisone inhibit diseases ofthe nose and lungs like hay fever, asthma and sinus disease. We use tissue samples from patients with disease vyho are undergoing surgery as a treatment for sinus disease to study the causes of their disease and how steroids improve their condition. This grant has previously supported many important studies on this topic in the past.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Method to Extend Research in Time (MERIT) Award (R37)
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Noel, Patricia
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Northwestern University at Chicago
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Liu, Xin; Hong, Xiumei; Tsai, Hui-Ju et al. (2018) Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine (Baltimore) 97:e0043
Ogasawara, Noriko; Klingler, Aiko I; Tan, Bruce K et al. (2018) Epithelial activators of type 2 inflammation: Elevation of thymic stromal lymphopoietin, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago, Illinois. Allergy 73:2251-2254
John Staniorski, Christopher; Price, Caroline P E; Weibman, Ava R et al. (2018) Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population. Int Forum Allergy Rhinol 8:495-503
Tan, Bruce K; Peters, Anju T; Schleimer, Robert P et al. (2018) Pathogenic and protective roles of B cells and antibodies in patients with chronic rhinosinusitis. J Allergy Clin Immunol 141:1553-1560
Imoto, Y; Kato, A; Takabayashi, T et al. (2018) Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43. Clin Exp Allergy 48:544-554
Liao, B; Liu, J-X; Li, Z-Y et al. (2018) Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy 73:1459-1469
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Homma, Tetsuya; Kato, Atsushi; Sakashita, Masafumi et al. (2017) Potential Involvement of the Epidermal Growth Factor Receptor Ligand Epiregulin and Matrix Metalloproteinase-1 in Pathogenesis of Chronic Rhinosinusitis. Am J Respir Cell Mol Biol 57:334-345
Poposki, Julie A; Klingler, Aiko I; Tan, Bruce K et al. (2017) Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immun Inflamm Dis 5:233-243
Banuelos, Jesus; Cao, Yun; Shin, Soon Cheon et al. (2017) Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils. PLoS One 12:e0177884

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