Abstract

See page 35

Public Health Relevance

We are trying to understand how anti-inflammatory steroids like cortisone inhibit diseases ofthe nose and lungs like hay fever, asthma and sinus disease. We use tissue samples from patients with disease vyho are undergoing surgery as a treatment for sinus disease to study the causes of their disease and how steroids improve their condition. This grant has previously supported many important studies on this topic in the past.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HL068546-31
Application #
8668536
Study Section
No Study Section (in-house review) (NSS)
Program Officer
Noel, Patricia
Project Start
1983-09-20
Project End
2019-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
31
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Tan, Bruce K; Peters, Anju T; Schleimer, Robert P et al. (2018) Pathogenic and protective roles of B cells and antibodies in patients with chronic rhinosinusitis. J Allergy Clin Immunol 141:1553-1560
Imoto, Y; Kato, A; Takabayashi, T et al. (2018) Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43. Clin Exp Allergy 48:544-554
Liao, B; Liu, J-X; Li, Z-Y et al. (2018) Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy 73:1459-1469
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Liu, Xin; Hong, Xiumei; Tsai, Hui-Ju et al. (2018) Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine (Baltimore) 97:e0043
Ogasawara, Noriko; Klingler, Aiko I; Tan, Bruce K et al. (2018) Epithelial activators of type 2 inflammation: Elevation of thymic stromal lymphopoietin, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago, Illinois. Allergy 73:2251-2254
John Staniorski, Christopher; Price, Caroline P E; Weibman, Ava R et al. (2018) Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population. Int Forum Allergy Rhinol 8:495-503
Weibman, Ava R; Huang, Julia He; Stevens, Whitney W et al. (2017) A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 7:1058-1064
Min, Jin-Young; Ocampo, Christopher J; Stevens, Whitney W et al. (2017) Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase. J Allergy Clin Immunol 139:130-141.e11
Banuelos, J; Cao, Y; Shin, S C et al. (2017) Immunopathology alters Th17 cell glucocorticoid sensitivity. Allergy 72:331-341

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