See page 35

Public Health Relevance

We are trying to understand how anti-inflammatory steroids like cortisone inhibit diseases ofthe nose and lungs like hay fever, asthma and sinus disease. We use tissue samples from patients with disease vyho are undergoing surgery as a treatment for sinus disease to study the causes of their disease and how steroids improve their condition. This grant has previously supported many important studies on this topic in the past.

National Institute of Health (NIH)
Method to Extend Research in Time (MERIT) Award (R37)
Project #
Application #
Study Section
No Study Section (in-house review) (NSS)
Program Officer
Noel, Patricia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Mahdavinia, Mahboobeh; Suh, Lydia A; Carter, Roderick G et al. (2015) Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia. J Allergy Clin Immunol 135:576-9
Mahdavinia, Mahboobeh; Carter, Roderick G; Ocampo, Christopher J et al. (2014) Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity. J Allergy Clin Immunol 133:1759-63
Cao, P-P; Zhang, Y-N; Liao, B et al. (2014) Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 44:690-700
Cho, Seong H; Hong, Seung J; Chen, Haimei et al. (2014) Plasminogen activator inhibitor-1 in sputum and nasal lavage fluids increases in asthmatic patients during common colds. J Allergy Clin Immunol 133:1465-7, 1467.e1-2
Hulse, Kathryn E; Chaung, Katrina; Seshadri, Sudarshan et al. (2014) Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 133:275-7.e1
Wu, I; Shin, S C; Cao, Y et al. (2013) Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes. Cell Death Dis 4:e453
Hsu, Joy; Avila, Pedro C; Kern, Robert C et al. (2013) Genetics of chronic rhinosinusitis: state of the field and directions forward. J Allergy Clin Immunol 131:977-93, 993.e1-5
Hulse, Kathryn E; Norton, James E; Suh, Lydia et al. (2013) Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy Clin Immunol 131:1075-83, 1083.e1-7
Cao, Yun; Bender, Ingrid K; Konstantinidis, Athanasios K et al. (2013) Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans. Blood 121:1553-62
Keswani, Anjeni; Kern, Robert C; Schleimer, Robert P et al. (2013) Role of interleukin-32 in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 13:13-8

Showing the most recent 10 out of 25 publications