1. Important scientific accomplishments supported by R37HL068546. Since submission of this proposal in the fall of 2008, the Pl and his laboratory have published a total of 51 manuscripts, of which 33 were supported by this proposal. Our productivity has been excellent recently; just in the first four and one half months of 2013, we have published eleven papers, of which seven appeared in the Journal of Allergy and Clinical Immunology, the leading Allergy-Immunology journal (impact factor approximately 11) and 7 were supported by this grant. This report is divided into sections that are oriented toward selected relevant ongoing projects. Many of the in vivo studies described in this report utilized patients with active chronic rhinosinusitis (CRS) and controls having surgery for non-inflammatory conditions. The Northwestern University (NU) group obtains and analyzes tissue samples, lavage and epithelial scrapings from over 250 tertiary care patients per year, enabling the translational work described in this proposal. One of the important studies in the proposal is to perform a clinical trial testing the impact of prednisone treatment on innate immunity, barrier, adaptive immunity and inflammatory responses in CRS. As described in this report, we are near completion of sample collection and we will very soon have a rich collection of important human samples from patients treated with prednisone, or not treated, with which to test some of the hypotheses described in the original proposal.

Public Health Relevance

We are trying to understand how anti-inflammatory steroids like cortisone inhibit diseases of the nose and lungs like hay fever, asthma and sinus disease. We use tissue samples from patients with disease vyho are undergoing surgery as a treatment for sinus disease to study the causes of their disease and how steroids improve their condition. This grant has previously supported many important studies on this topic in the past.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL068546-34
Application #
9320828
Study Section
Special Emphasis Panel (NSS)
Program Officer
Noel, Patricia
Project Start
1983-09-20
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
34
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Liu, Xin; Hong, Xiumei; Tsai, Hui-Ju et al. (2018) Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy. Medicine (Baltimore) 97:e0043
Ogasawara, Noriko; Klingler, Aiko I; Tan, Bruce K et al. (2018) Epithelial activators of type 2 inflammation: Elevation of thymic stromal lymphopoietin, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago, Illinois. Allergy 73:2251-2254
John Staniorski, Christopher; Price, Caroline P E; Weibman, Ava R et al. (2018) Asthma onset pattern and patient outcomes in a chronic rhinosinusitis population. Int Forum Allergy Rhinol 8:495-503
Tan, Bruce K; Peters, Anju T; Schleimer, Robert P et al. (2018) Pathogenic and protective roles of B cells and antibodies in patients with chronic rhinosinusitis. J Allergy Clin Immunol 141:1553-1560
Imoto, Y; Kato, A; Takabayashi, T et al. (2018) Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43. Clin Exp Allergy 48:544-554
Liao, B; Liu, J-X; Li, Z-Y et al. (2018) Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes. Allergy 73:1459-1469
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Weibman, Ava R; Huang, Julia He; Stevens, Whitney W et al. (2017) A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 7:1058-1064
Min, Jin-Young; Ocampo, Christopher J; Stevens, Whitney W et al. (2017) Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase. J Allergy Clin Immunol 139:130-141.e11
Banuelos, J; Cao, Y; Shin, S C et al. (2017) Immunopathology alters Th17 cell glucocorticoid sensitivity. Allergy 72:331-341

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