Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

Public Health Relevance

Diseases of the heart often involve changes in the stiffness of the heart. We have developed a new imaging method that displays the stiffness of heart tissue. We propose animal and human studies to determine the potential of this method to reliably detect and predict cardiac diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Method to Extend Research in Time (MERIT) Award (R37)
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Biomedical Imaging Technology Study Section (BMIT)
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Buxton, Denis B
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Duke University
Biomedical Engineering
Schools of Engineering
United States
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Hollender, Peter; Kuo, Lily; Chen, Virginia et al. (2017) Scanned 3-D Intracardiac ARFI and SWEI for Imaging Radio-Frequency Ablation Lesions. IEEE Trans Ultrason Ferroelectr Freq Control 64:1034-1044
Hollender, Peter; Lipman, Samantha L; Trahey, Gregg E (2017) Thee-Dimensional Single-Track-Location Shear Wave Elasticity Imaging. IEEE Trans Ultrason Ferroelectr Freq Control 64:1784-1794
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Hollender, Peter; Bottenus, Nick; Trahey, Gregg (2015) A multiresolution approach to shear wave image reconstruction. IEEE Trans Ultrason Ferroelectr Freq Control 62:1429-39
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Hollender, Peter J; Rosenzweig, Stephen J; Nightingale, Kathryn R et al. (2015) Single- and multiple-track-location shear wave and acoustic radiation force impulse imaging: matched comparison of contrast, contrast-to-noise ratio and resolution. Ultrasound Med Biol 41:1043-57
Vejdani-Jahromi, Maryam; Nagle, Matt; Trahey, Gregg E et al. (2015) Ultrasound shear wave elasticity imaging quantifies coronary perfusion pressure effect on cardiac compliance. IEEE Trans Med Imaging 34:465-73
Pinton, Gianmarco; Trahey, Gregg; Dahl, Jeremy (2014) Spatial coherence in human tissue: implications for imaging and measurement. IEEE Trans Ultrason Ferroelectr Freq Control 61:1976-87

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