Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

Public Health Relevance

Diseases of the heart often involve changes in the stiffness of the heart. We have developed a new imaging method that displays the stiffness of heart tissue. We propose animal and human studies to determine the potential of this method to reliably detect and predict cardiac diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Method to Extend Research in Time (MERIT) Award (R37)
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Biomedical Imaging Technology Study Section (BMIT)
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Buxton, Denis B
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Duke University
Biomedical Engineering
Biomed Engr/Col Engr/Engr Sta
United States
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Vejdani-Jahromi, Maryam; Freedman, Jenna; Nagle, Matthew et al. (2016) Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography. J Am Soc Echocardiogr :
Vejdani-Jahromi, Maryam; Nagle, Mathew; Jiang, Yang et al. (2016) A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart. IEEE Trans Ultrason Ferroelectr Freq Control 63:1288-95
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Hollender, Peter; Bottenus, Nick; Trahey, Gregg (2015) A multiresolution approach to shear wave image reconstruction. IEEE Trans Ultrason Ferroelectr Freq Control 62:1429-39
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Pinton, Gianmarco; Trahey, Gregg; Dahl, Jeremy (2014) Spatial coherence in human tissue: implications for imaging and measurement. IEEE Trans Ultrason Ferroelectr Freq Control 61:1976-87
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Byram, Brett; Jakovljevic, Marko (2014) Ultrasonic multipath and beamforming clutter reduction: a chirp model approach. IEEE Trans Ultrason Ferroelectr Freq Control 61:428-40

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