Hypothetically psychosis-prone subjects (N = 343) and control subjects (N = 158), who were identified and interviewed approximately ten years earlier, will be followed up and re- interviewed to determine their incidence of clinical attention for psychosis. Other dependent variables will be diagnostic category of psychosis, incidence of mood disorders, incidence of schizotypal personality disorder, and level of social adjustment. The hypothetically psychosis-prone subjects were originally identified by their deviant scores on three scales produced by this project: the Perceptual Aberration-Magical Ideation Scale (N = 195), the Physical Anhedonia Scale (N = 74), and the Impulsive Nonconformity Scale (N = 74). (Subjects with high scores on these scales have been found in previous studies to show many traits and symptoms expected in psychosis-prone individuals. Three subjects identified by the Perceptual Aberration-Magical Ideation Scale were found at a 25-month follow-up to have already received clinical attention for psychosis). Independent variables, other than group membership, will be scores on each of the three scales mentioned above, as well as handedness and ratings of several symptoms from the initial interviews 10 years earlier. Three interview schedules will be used in the follow-up: a modified Schedule for Affective Disorders and Schizophrenia- Lifetime version a revised version of the Social Adjustment Scale, and the Schedule for Schizotypal Personalities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37MH031067-12
Application #
3486458
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-09-01
Project End
1996-05-31
Budget Start
1992-06-01
Budget End
1993-05-31
Support Year
12
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kwapil, T R (1998) Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders. J Abnorm Psychol 107:558-65
Kwapil, T R (1996) A longitudinal study of drug and alcohol use by psychosis-prone and impulsive-nonconforming individuals. J Abnorm Psychol 105:114-23
Kwapil, T R; Chapman, J P; Chapman, L J et al. (1996) Deviant olfactory experiences as indicators of risk for psychosis. Schizophr Bull 22:371-82
Miller, E N; Fujioka, T A; Chapman, L J et al. (1995) Hemispheric asymmetries of function in patients with major affective disorders. J Psychiatr Res 29:173-83
Miller, E N; Fujioka, T A; Chapman, L J et al. (1995) Psychometrically matched tasks for assessment of hemispheric asymmetries of function. Brain Cogn 28:1-13
Miller, M B; Chapman, J P; Chapman, L J et al. (1995) Task difficulty and cognitive deficits in schizophrenia. J Abnorm Psychol 104:251-8
Chapman, L J; Chapman, J P; Kwapil, T R et al. (1994) Putatively psychosis-prone subjects 10 years later. J Abnorm Psychol 103:171-83
Miller, M B; Chapman, L J; Chapman, J P et al. (1993) Slowness and the preceding preparatory interval effect in schizophrenia. J Abnorm Psychol 102:145-51
Kwapil, T R; Chapman, L J; Chapman, J P (1992) Monaural and binaural story recall by schizophrenic subjects. J Abnorm Psychol 101:709-16
Miller, M B; Chapman, L J; Chapman, J P et al. (1990) Schizophrenic deficit in span of apprehension. J Abnorm Psychol 99:313-6

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